Study of Analgesic and Anti-inflammatory Effects of Lappaconitine Gelata  

作　　者：王英姿 肖勇庆 张超 孙秀梅 

机构地区：[1]College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine,Beijing 100102, China [2]China Academy of Traditional Chinese Medicine,Beijing 100700, China [3]College of Pharmacy, Shandong University of Traditional Chinese Medicine,Jinan 250014, China

出　　处：《Journal of Traditional Chinese Medicine》2009年第2期141-145,共5页中医杂志（英文版）

摘　　要：Objective: To explore the analgesic and anti-inflammatory effects of lappaconitine gelata (LA). Methods: The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate method in the mouse, and the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were used for investigation on the analgesic and anti-inflammatory effects of LA. Results: The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate methods was significantly inhibited by LA. In addition, the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were all significantly suppressed by LA. Conclusion: LA has the analgesic and anti-inflammatory effects.Objective： To explore the analgesic and anti-inflammatory effects of lappaconitine gelata （LA）. Methods： The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate method in the mouse, and the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were used for investigation on the analgesic and anti-inflammatory effects of LA. Results： The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate methods was significantly inhibited by LA. In addition, the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were all significantly suppressed by LA. Conclusion： LA has the analgesic and anti-inflammatory effects.

关 键 词：lappaconitine gelata PHARMACODYNAMICS analgesic effect anti-inflammatory effect animal test 

分 类 号：R285.5[医药卫生—中药学]