葡萄糖引起胰岛素分泌的分子机制  

Molecular Mechanism of Insulin SecretionInduced by Glucose Elicits

作　　者：杨炎华[1] 朱智勇[1] 

机构地区：[1]昆明医学院生理学教研室

出　　处：《昆明医学院学报》1998年第2期83-85,共3页Journal of Kunming Medical College

摘　　要：循环血液中的葡萄糖水平是决定胰岛素释放的主要因素．在胰岛β细胞内，葡萄糖主要经糖酵解途径释放ＡＴＰ，关闭ＡＴＰ敏感的Ｋ＋通道，引起膜去极化，最后由于细胞内Ｃａ２＋浓度升高而激活胞吐机制，释放胰岛素．The glucose level in the circulating blood is a major factor for the release of insulin. In the β-cell of insulin, glucose releases ATP by the means of glucogenolysis. Closing ATP-sensitive K+ channel leads to membrane depolarization, which releases insulin secretion due to the rise of Ca2+ concentration stimulating exocytosis.

关 键 词：胰岛素 葡萄糖 Β细胞 K^+-ATP通道 钙离子 

分 类 号：Q45[生物学—生理学] Q532.3