乙型肝炎重叠丁型肝炎病毒感染的血清学检测及临床分析  

SEROLOGICAL AND CLINICAL ANALYSIS ON VIRUS B HEPATITISSUPERINFECTED BY HEPATITIS D VIRUS

作　　者：王金花[1] 武菲菲[1] 孙花芬[1] 陈志姣[1] 王菊英[1] 希向红 哈丽阳[1] 

机构地区：[1]宁夏医学院附属医院传染科

出　　处：《宁夏医学院学报》1998年第2期18-20,共3页Journal of Ningxia Medical College

摘　　要：对８８９例乙肝患者进行ＨＤＡｇ、抗ＨＤＶ、抗ＨＤＶ－ＩｇＭ标志检测。乙丁重叠感染率为４．７２％，男性组（５．６４％）略高于女性组（３．８８％），５０岁以上年龄组（７．９５％）高于其它各年龄组。急性乙肝、慢肝轻度、慢肝中度、慢肝重度、重症肝炎、肝硬变、肝癌病人ＨＤＶ感染率依次为１．４７％、２．０２％、３．０３％、５．３０％、５．０８％、７．８８％及１２．５％，提示ＨＤＶ感染对ＨＢＶ感染的慢性化和肝硬变的形成起着一定的促进作用。重叠组与对照组的黄疸发生峰值、ＡＬＴ升高程度及ＡＬＴ复常时间之间有明显差异，提示乙丁重叠对病情加重、病程延长起着重要作用。HDV　markers(HDAg,antiHDV,antiHDVIgM)　were　determined　in　889　patients　with　hepatitis　B.The　positive　rate　of　superinfection　of　hepatitis　D　virus　in　patients　with　virus　B　hepatitis　was　4.72%.The　rate　of　male　(5.64%)　was　higher　than　that　of　female　(3.88%).The　rate　in　age　group　above　50　(7.95%)　was　higher　than　the　rest　groups.We　also　noticed　that　the　rates　of　HDV　superinfection　were　1.47%,2.02%,3.03%,5.30%,5.08%,7.88%　and　12.5%　in　the　groups　of　acute　hepatitis,chronic　light　hepatitis,chronic　moderate　hepatitis,chronic　severe　hepatitis,fulminant　hepatitis,hepatic　cirrhosis　and　liver　carcinoma　respectively.There　were　statistically　significant　differences　in the degree of　jaundice,ALT　and　the　persistant duration　of　peak ALT　between　the　HDV　superinfection　and the control group. These finding indicated that HDV superinfection was important in　the　pathogenesis　of　chronic　hepatitis　B　and　in　the　worsening　of　the　hepatopathy　from　inflammatory　liver　lesion　to　cirrhosis.There　were　no　statistically　significant　differences　in HBV　markers　of　HDV　superinfection　in　this　study.

关 键 词：乙型肝炎病毒 丁型肝炎病毒 重叠感染 诊断 

分 类 号：R512.604[医药卫生—内科学]