2型糖尿病对急性心肌梗死溶栓治疗的影响  

作　　者：叶威巍[1] 许飞来[2] 郭亚颍 

机构地区：[1]复旦大学附属华山医院内分泌科,上海200040 [2]安徽省颍上县人民医院

出　　处：《中国医疗前沿》2009年第6期33-34,共2页China Healthcare Innovation

摘　　要：目的评估急性心肌梗死(AMI)合并2型糖尿病(T2DM)溶栓治疗疗效及其影响因素的分析。方法100例AMI住院患者按照有无糖尿病史分为糖尿病组(n=32)和非糖尿病组(n=68),均在发病12小时内进行尿激酶溶栓治疗,比较两组近期疗效并分析其影响因素。结果(1)DM组的血管再通率明显低于非DM组(39.5%vs67.6%,P<0.05)。(2)与非DM组比较,DM组的空腹血糖(11.2±2.9mmol/Lvs5.4±1.3mmol/L,P<0.05)、高血压(53.1%vs48.5%,P<0.05)、高血脂(62.5%vs58.8%)、心源性休克(15.63%vs10.29%,P<0.05)、出血(9.38%vs5.88%,P<0.05)及死亡率(18.75%vs10.29%,P<0.05)显著升高。结论静脉溶栓治疗急性心肌梗死伴T2DM的近期疗效较差,高血糖、高血压、高血脂是其重要影响因素。Objective This study aimed to investigate the relation between type 2 diabetes（T2DM） and the treatment of acute myocardial infarction （AMI）. Method 100 patients with AMI were divided into two groups with（n=32） and without（n=68） diabetes. All patients were received thrombolytic therapy using urokinase within 12 hours. The two groups were compared and the influencing factors were analysised. Result （1）The rate of the recanalization was sigonificanfly lower in the group with diabetes than the control one. （2） In the group with diabetes mellitus, the level of fasting glucose was higher than the control one. （11.2 ± 2.9vs 6.8± 1. 3,P〈0.05）, and the rate of hypertension（53.1% vs 48.5%, P 〈 0.05）,hyperlipoidemia（62.5 % vs 58.8 % , P 〈 0.05）, cardiogenic shock（15.63 % vs 10.29 % , P 〈 0.05） , hemorrhage（9.38 % vs 5.88 % , P 〈 0.05） and mortality（18.75 % vs10.29 % , P 〈 0.05） are all higher than the group without diabetes mellitus. Conclusion A poorer short-term curative effect on the AMI with T2DM than the control one when thrombolytic therapy was used.

关 键 词：糖尿病 急性心肌梗死 溶栓治疗 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]