麝香酮对完全性脑缺血大鼠的保护作用  

Protective Effects of Muskone on Rats with Complete Cerebral Ischemia

作　　者：孙蓉[1] 张作平 黄伟[3] 吕丽莉[1] 任海勇 

机构地区：[1]山东省中医药研究院,济南250014 [2]济南杏林生物技术有限公司,济南250101 [3]山东中医药大学,济南250355

出　　处：《中药新药与临床药理》2009年第3期197-200,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：山东省自然基金项目(Y2003C02);济南市重大科技招标项目(064036)

摘　　要：目的观察麝香酮对大鼠完全性脑缺血后再灌流期间血脑屏障及神经病理改变的影响。方法取Wistar大鼠,采用四血管阻断(4VO)法制备全脑缺血再灌流损伤模型,将成模大鼠随机分为麝香酮高、中、低剂量组(3.6,1.8,0.9mg/kg),并设假手术组,模型组,阳性对照药尼莫地平组(10.8mg/kg),共6组,每组12只。对大鼠神经行为学,缺血区脑组织超氧化物歧化酶(SOD),丙二醛(MDA)含量,脑组织兴奋性氨基酸(EAA)含量进行检测。结果麝香酮组可明显增加大鼠脑组织SOD含量,降低MDA含量,减轻缺血、缺氧造成的EAA含量增加,抑制EAA所导致的兴奋性神经毒性。结论麝香酮对4VO法所致完全性脑缺血模型具有明显的保护作用。Objective To observe the effect of muscone on the blood - brain barrier and neuropathological changes after complete cerebral ischemia/reperfusion of rats. Methods The global cerebral ischemia/reperfusion injury model was established by the four- vessel occlusion（4VO） method, and then the model animals were given high - , middle - and low -dose muscone. Meanwhile, sham - operation group, model group, and positive control group were also set up. The rats neuroethology behavior, and the contents of superoxide dismutase（SOD）, malondialdehyde（MDA） and excitatory amino acid （EAA） in ischemic brain tissue were examined. Results Muscone increased SOD content, lowered MDA content, reduced the increase of EAA content caused by ischemia and hypoxia, and inhibited the excitatory neurotoxicity caused by EAA. Conclusion Muscone has obvious protective effect on rats with complete cerebral ischemia/reperfusion injury.

关 键 词：麝香酮 脑缺血再灌注损伤 超氧化物歧化酶 丙二醛 兴奋性氨基酸 

分 类 号：R285.5[医药卫生—中药学]