乳康平胶囊对乳腺增生大鼠肝脏和乳腺中微量元素的影响  

Changes of Trace Elements in Liver and Breast of Mammary Gland Hyperplasia Rats Treated by Rukangping Capsules

作　　者：李挥[1,2] 郝蕾[3] 范斌[1] 李春香[3] 

机构地区：[1]国家环保产品质量监督检验中心河北省食品安全实验室,石家庄050051 [2]河北大学化学学院,保定071002 [3]河北医科大学中医学院,石家庄050000

出　　处：《中药新药与临床药理》2009年第3期228-230,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：河北省科技支撑项目(07276709D);河北省卫生厅项目(05045)

摘　　要：目的研究乳康平胶囊对SD大鼠乳腺增生模型中肝脏、乳腺中微量元素的影响。方法实验分为空白组、模型组、乳康平组,逍遥丸组和三苯氧胺组。取各动物的肝脏、乳腺,经消化处理后测定铜(Cu)、锌(Zn)、铁(Fe)、锰(Mn)、硒(Se)变化情况。结果与模型组比较,各治疗组动物肝脏和乳腺中微量元素的变化均有显著性差异,能改善乳腺增生大鼠肝脏和乳腺中失调的微量元素含量。结论乳康平胶囊可有效地调节乳腺增生大鼠肝脏和乳腺中的微量元素。Objective To study the effects of Rukangping Capsules （RC） on trace elements in liver and breast of mammary gland hyperplasia rats. Methods SD rats were divided into blank group, model group, RC group, Xiaoyao pills group and tamoxifen group. The changes of content of copper （Cu）, zinc（Zn）, iron （Fe）, manganese （Mn）, selenium （Se） in liver and breast were observed. Results Compared with the model group, the hepatic and mammary trace element content were improved in the three medication groups and the difference being significant. Conclusion RC can regulate the trace elements content in liver and breast of mammary gland hyperplasia rats.

关 键 词：乳康平 SD大鼠 乳腺增生 微量元素 肝脏 乳腺 

分 类 号：R285.5[医药卫生—中药学]