正交试验优选姜油树脂凝胶的处方  

Optimization of preparation formulation of ginger oleoresin gel by orthogonal test

作　　者：董得时[1] 陈艳伟[1] 汤新强[1] 谭爱萍[1] 

机构地区：[1]大连医科大学附属第一医院西药局,辽宁大连116011

出　　处：《大连医科大学学报》2009年第3期335-336,共2页Journal of Dalian Medical University

摘　　要：[目的]根据姜油树脂的物理化学特性,研制适合临床应用的稳定的姜油树脂制剂的处方。[方法]采用正交设计试验考察卡波姆-940的用量,甘油浓度以及吐温-80浓度对姜油树脂凝胶的外观和稳定性的影响。[结果]姜油树脂凝胶剂处方的最佳组合为:1 g/100 mL的卡波姆-940,5%的甘油,3%的吐温-80,其制成的制剂质地均匀,细腻,黏度适中,涂展性好;4000 r/min离心60 min,稳定,无分层现象。[结论]姜油树脂凝胶剂稳定性良好,该处方合理可用。[ Objective] This work develops a stable prescription of ginger oleoresin gel which is suitable for clinical application according to its physical -chemistry characteristics. [ Methods] Orthogonal experimental design was used to investigate the influence of carbomer- 940 dosage, glycerol and tween -80 concentrations to appearance and stability of ginger oleo- resin. [ Results] Optimized combination for the prescription of ginger oleoresin gel was carbomer - 940 （ 1 g/100 mL）, glycerol （5%） and tween-80 （3%）. Such preparation had uniform texture, moderate viscosity and good malleability. Under centrifugation （4000 r/rain, 60 rain） , It was stable with no stratification phenomenon. Its appearance and malleability at room temperature did not change for 3 months. [ Conclusion] The ginger oleoresin gel described in the present study has good stability and the formulation is rational and practicable.

关 键 词：姜油树脂凝胶 正交试验 处方优化 

分 类 号：R283[医药卫生—中药学]