HLA基因多态性与原发性高血压的相关性研究进展  

Research advancement of correlation between essential hypertension and genetic polymorphism of HLA

作　　者：裴梓峰[1] 李岩[1] 马威[1] 徐飞[1] 

机构地区：[1]大连医科大学人体解剖学教研室,辽宁大连116044

出　　处：《大连医科大学学报》2009年第3期359-363,共5页Journal of Dalian Medical University

摘　　要：人类白细胞抗原(HLA)由称人类主要组织相容性复合体(MHC),它由一组具有高度多态性和连锁的不均衡性基因群体构成,其研究主要于器官移植、免疫应答、法医学、人类学和疾病相关性等领域。本文介绍了HLA的基因结构、多态性及HLA-Ⅱ类基因多态性与EH相关性等方面内容。Human leucocyte antigen （HLA） is also called major histocompatibility complex （MHC）. It is a group of genes with an extremely high polymorphism and linked malconformation. Recently, the applications of HLA have extended to the fields of illness correlation, organ transplantation, immune response, forensic medicine, anthropology and so on. The genetic structure and polymorphism of HLA, and correlation between genetic polymorphism of HLA - Ⅱ alleles and essential hypertension （EH） are reviewed in this paper.

关 键 词：人类白细胞抗原 人类主要组织相容性复合体 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]