TNF-α、INF-γ和EPO与肿瘤伴ACD造血功能低下的相关性  

The relationship between TNF-α,INF-γ,EPO and reduced erythropoiesis in cancer with anemia of chronic disease

作　　者：孙艳[1] 刘新月[2] 张纯[2] 刘革修[3] 

机构地区：[1]广东药学院生命科学与生物制药学院,广东广州510006 [2]华中科技大学同济医学院,湖北武汉430022 [3]暨南大学医学院血液病研究所,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2009年第2期139-142,共4页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金项目(30670902);武汉市科委重点攻关项目(996008172)

摘　　要：目的:探讨肿瘤坏死因子α(TNF-α)、干扰素γ(INF-γ)和红细胞生成素(EPO)对肿瘤伴慢性病贫血(ACD)造血功能的影响。方法:检测肿瘤患者铁代谢参数;ELISA法检测患者血清TNF-α、IFN-γ和EPO水平;观察3种细胞因子及患者血清对骨髓红系集落生成单位(CFU-E)生成的影响。结果:肿瘤伴ACD患者血清EPO水平高于正常对照,而低于IDA患者;血清TNF-α、IFN-γ水平显著升高,且与血球压积、血清铁水平负相关;TNF-α、IFN-γ可抑制正常骨髓CFU-E生成,患者血清可抑制自身骨髓CFU-E生成,rhEPO可部分纠正细胞因子对CFU-E的抑制。结论:TNFα-、IFN-γ和EPO与肿瘤伴ACD造血功能低下有关。Aim：To investigate the effect of EPO, TNF-α and IFN-γ on erythropoiesis in cancer with anemia of chronic disease （ACD）. Methods： The iron metabolic parameters were measured by regular methods. EPO, TNF-α and IFN-γ levels in sera of cancers with ACD were detected by ELISA. The action of three cytokines and serum from patients themselves on erythroid colony forming unit-erythrocyte （CFU-E） growth of normal people＇s and patients＇ bone marrow were observed. Results： EPO levels in sera of cancers with ACD were higher than those in normal controls, while lower than those in cancers with iron-deficiency anemia. Levels of TNF-α and IFN-γ in sera of cancers with ACD were greatly increased and negatively correlated with hematocrit（Hct） and hemoglobin levels.- TNF-α and IFN-γ could inhibit normal bone marrow CFU-E growth. Bone marrow CFU-E yields of cancers with ACD could also be suppressed by their own sera. The inhibitory effects of TNF-α and IFN-γ on CFU-E growth could be partially reverted by adding rhEpo. erythropoiesis in cancer with anemia Conclusion：EPO, TNF-α and IFN-γ were associated with reduced of chronic disease.

关 键 词：肿瘤坏死因子α 干扰素Γ 红细胞生成素 肿瘤 慢性病贫血 

分 类 号：R556.9[医药卫生—血液循环系统疾病]