产ESBLs大肠埃希菌的检出与耐药趋势分析  

Detection and drug-resistance tendency of extended-spectrum β-lactamase-producing Escherichia coli

作　　者：张芳[1] 李玉敏[1] 崔琴[1] 常军霞[1] 

机构地区：[1]北京通州区潞河医院

出　　处：《中国感染控制杂志》2009年第3期195-197,共3页Chinese Journal of Infection Control

摘　　要：目的 了解产超广谱β内酰胺酶（ESBLs）大肠埃希菌的检出及其耐药变化，为临床合理使用抗菌药物提供参考。方法收集某院2006年1--12月间临床标本分离的大肠埃希菌，对其产ESBLs株及耐药情况与2002年进行比较。结果2006年分离的大肠埃希菌中产ESBLs株占65．54％（175／267），与2002年的47．92％（46／96）比较，显著增加（X^2=9．21，P〈0．05）。产ESBLs大肠埃希菌对氨曲南的敏感率2006年为24．00％，较2002年的52．17％显著下降（X^2=13．80，P〈0．05）；对其他抗菌药物的敏感率差异无统计学意义，亚胺培南仍对产ESBLs大肠埃希菌有良好的抗菌活性。结论产ESBLs大肠埃希菌的检出有增加趋势，且耐药率高，应引起临床重视。Objective To investigate the detection and change in drug-resistance of extended-spectrum β-lactamase （ESBLs）-producing Escherichia coli, so as to provide reference for the rational use of antimicrobial agents in clinic. Methods Escherichia coli isolated from clinic in a hospital between January-December, 2006 were collected, the detection of ESBLs and drug-resistance were compared with those of 2002. Results The rate of ESBLs-producing Escherichia coli isolated in 2006 was 65. 54% （175/267）, which increased obviously compared with 47. 92% （46/ 96） isolated in 2002 （X^2 = 9. 21, P〈0. 05）. The susceptibility rate of ESBLs-producing Escherichia coli to imipenem in 2006 was 24. 00~, which decreased obviously compared with 52. 17% in 2002 （X^2 = 13. 80, P%0. 05） ; The susceptibility rates to the other antimicrobial agents had no statistic significance, imipenem still had ideal activity a- gainst ESBLs-producing Escherichia coli. Conclusion There is increasing tendency in the detection of ESBLs-producing Escherichia coli, and drug-resistance is high, which should be paid attention.

关 键 词：大肠埃希菌 超广谱Β内酰胺酶 抗药性 微生物 

分 类 号：R378.21[医药卫生—病原生物学]