血管紧张素转化酶2-血管紧张素1-7-Mas轴的研究进展  

Recent advances in the angiotensin - converting enzyme2 - angiotensin （ 1 - 7 ） - Mas axis

作　　者：史婷婷[1] 杨金奎[1] 

机构地区：[1]首都医科大学附属同仁医院,北京100730

出　　处：《中国医学创新》2009年第16期160-163,共4页Medical Innovation of China

基　　金：国家自然科学基金资助项目（No.30671001）

摘　　要：经典的肾素血管紧张素系统在维持动脉血压平衡，水电解质平衡，调节细胞增生及分化中起着重要的作用。血管转化酶2，血管紧张素1-7的受体Mas等新成员的发现使人们对这一系统的认识进一步深化。血管紧张素1-7，及其在体内主要的合成酶ACE2，和受体Mas组成的调节轴可产生广泛的生理学效应，拮抗血管转化酶-血管紧张素Ⅱ-AT1受体调节轴的效应，从而为高血压，心衰等心血管疾病和肾脏，肝脏等系统疾病的药物治疗提供新的思路和方法。The classic system of renin - angiotensin system plays an important role in regulating arterial blood pres- sure, water - electrolyte balance, cellular proliferation and differentiation. The recent discoveries of new components of this system such as ACE2 and Mas receptor deepen our research in the system. Angiotensinl -7, its syozyme ACE2 and its recep- tor Mas constitute an axis which can evokes many protective effects. This axis has a counter - regulatory role towards the ACE - AngⅡ- AT1R axis. It can open great potential in treating the cardiovascular diseases such as hypertension and chronic heart diseases, and other systemic diseases such as in kidney and liver.

关 键 词：血管紧张素转化酶2 血管紧张素1-7 血管紧张素1-7受体 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]