基因转染猪皮在大面积深度烧伤患者微粒皮移植中的临床应用  

Clinical application of gene-transfected pig's skin on human autogenous granule skin graft

作　　者：刘漪沦[1] 马兵[1] 刘月明[1] 李晨阳[1] 许雪峰[1] 魏平[2] 

机构地区：[1]成都医学院第一附属医院烧伤整形科,四川成都610500 [2]武警四川省消防总队医院烧伤科,四川成都610072

出　　处：《四川医学》2009年第5期623-624,共2页Sichuan Medical Journal

基　　金：四川省科技厅应用基础研究项目(2008JY0082)

摘　　要：目的研究基因转染猪皮作为覆盖物在大面积烧伤患者自体微粒皮移植中的临床应用效果。方法在自体微粒皮移植中应用基因转染猪皮作为覆盖物,以新鲜猪皮作为对照,采用随机开放设计,观察猪皮覆盖物排异反应情况与相应微粒皮移植后创面愈合情况。结果试验组基因转染猪皮开始发生排异反应的时间为第(19.6±3.4)天,对照组新鲜猪皮开始排异时间为第(15.2±3.7)天,试验组、对照组微粒皮移植术后6周创面愈合率分别为(80.3±2.5)%、(71.6±1.9)%;差异均有统计学意义。结论应用基因转染猪皮作为微粒皮移植覆盖物,排异反应发生时间延迟,微粒皮移植术后创面愈合较新鲜猪皮好。Objective To explore the clinical application of gene-transfected pig＇s skin as the coveting of human autogenous granule skin graft. Methods Gene-transfected pig＇ s skin was applied to autogenous granule skin graft transplanted to human wound surface. Fresh miniature＂ pig＇ s skin was applied as control. Observation was performed on rejection and restoration process of human wound surface after autogenous granule skin transplanfion applied by either of the two kind of pig＇ s skin coveting. Results （ 19.6± 3.4）were the average days before rejection occured on the trial group. The average days before rejcefion occured on the control group were（ 15.2 ± 3.7 ）. The trial group had a higher wound healing rate at the 6rd weeks post-graft. Conclusion time rejection occurrence was delayed in the trial group which applied gene-gransfected pig＇ s skin as the covering of autogenous granule skin graft compared with the control group. And the growth of autogenous granule skin graft in the trial group were better than the contol group.

关 键 词：皮肤移植 生物敷料 烧伤 

分 类 号：R644[医药卫生—外科学]