甲亢方对甲亢大鼠甲状腺激素水平和甲状腺病理改变的影响  

Effect of hyperthyroidism decoction on thyroid hormone and thyroid pathological changes of experimental hyperthyroid rats

作　　者：朱传湘[1] 阳春林[2] 胡方林[1] 易法银[1] 张国民[1] 

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学2006级硕士研究生

出　　处：《中国医师杂志》2009年第5期609-611,共3页Journal of Chinese Physician

基　　金：湖南省教育厅资助项目（05C362）

摘　　要：目的观察甲亢方（益气滋阴方）对实验性甲亢大鼠甲状腺激素水平和甲状腺病理改变的影响。方法将40只大鼠随机分成正常组、甲亢模型组、甲亢方组、西药对照组，后三组用优甲乐（左甲状腺素钠）灌服建立甲亢大鼠模型，甲亢方组以甲亢方对模型进行干预，西药对照组以丙基硫氧嘧啶对模型进行干预。采用放射免疫法测定血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促甲状腺激素（TSH）含量，用光学显微镜观察甲状腺病理改变。结果与模型组相比，甲亢方组血清T3、T4、FT3、FT4含量降低（P〈0．01），TSH含量增高（P〈0．05）；甲亢方能改善甲亢大鼠甲状腺病理改变。结论甲亢方能明显改善甲亢大鼠甲状腺功能。Objective To observe the effect of hyperthyroidism decoction on thyroid hormone and thyroid pathological changes of experimental hyperthyroid rats. Methods 40 rats were randomly divided into four groups： Normal group,hyperthyreosis model group, western drugs control group and hyperthyroidism decoction group. The model rats were constructed by drenching Youjiale. Hyperthyroidism decoction group were given hyperthyroidism decoction of respective dosage, western drugs control group were given propylthiouracil. The serum contents of T3 , T4,FT3 ,FT4 and TSH were determined by radio-immunity method, the thyroid pathological changes effected by hyperthyroidism decoction were observed. Results Compared with model group, the contents of serum T3 , T4,FT3 ,FT4 of hyperthyroidism decoction group were decreased, while the contents of serum TSH were increased. Hyperthyroidism decoction may improve thyroid pathological changes of experimental hyperthyroid rats. Conclusion Hyperthyroidism decoction can effectively improve the thyroid function of experimental hyperthyroid rats.

关 键 词：益气养阴 甲状腺功能亢进症/中药疗法 甲状腺激素类/血液 甲状彬病理学 

分 类 号：R581.1[医药卫生—内分泌]