PTPN22基因多态性与中国广东汉族人群RA发病的相关性研究  

Associations of Protein Tyrosine Phosphatase Nonreceptor 22(PTPN22) Gene Polymorphisms with RA in the Han Population of Guangzhou in China

作　　者：赵丽[1] 裘宇容[1] 

机构地区：[1]南方医科大学南方医院检验科,广州510515

出　　处：《热带医学杂志》2009年第5期493-495,共3页Journal of Tropical Medicine

基　　金：广东省自然科学基金(No.8151051501000089)

摘　　要：目的检测中国广东地区汉族人群中类风湿关节炎(RA)发病与蛋白酪氨酸磷酸酶非受体型22(PTPN22)基因Arg620Trp/1858C>T多态性的关系。方法采用PCR-RFLP技术分析了广东汉族人群中148例散发RA患者和150例健康对照者PTPN22 1858位点基因型。结果在中国广东地区汉族人群中PTPN22 1858位点仅存在等位基因C,与RA的发病无关。结论中国广东地区汉族人群中,PTPN22 Arg620Trp多态性与RA的发病无关;PTPN22基因可能存在其他多态性位点,需作进一步探讨。Objective To investigate the relationship between the polymorphism site （R620W） of gene protein tyrosine phosphatase nonreceptor 22 （PTPN22） and the rheumatoid arthritis（RA） in Han population in Guangzhou city of China. Methods One hundred forty-eight patients with RA and 150 healthy people were investigated. PTPN22 gene polymorphism ＋1858C〉T polymorphism was detected by polymerase chain reaction restriction fragment length polymorphism （PCR-RFLP）. Results The 1858 T allele was presented in none of the samples and only C allele was detected. Conclusion PTPN22 polymorphism （R620W） not associated with RA in the Chinese population from Guangzhou city of China. Further studies should be done to confirm this observation.

关 键 词：类风湿性关节炎 蛋白酪氨酸磷酸酶非受体型22 基因多态性 

分 类 号：R593.22[医药卫生—内科学]