糖尿病肾病合并冠心病患者C反应蛋白及巨噬细胞移动抑制因子的改变  

The Changes of Plasma High-Sensitivity C-Reactive Proteins and Macrophage Migration Inhibitory Factor in Patients with Diabetes Nephropathy and Coronary Heart Disease

作　　者：徐向明[1] 何坚[1] 贺军[1] 

机构地区：[1]增城市新塘医院急诊科,增城511340

出　　处：《热带医学杂志》2009年第5期547-549,共3页Journal of Tropical Medicine

摘　　要：目的通过检测糖尿病肾病合并冠心病患者血浆高敏C反应蛋白(hsCRP)及巨噬细胞移动抑制因子(MIF),了解hsCRP及MIF在糖尿病肾病合并冠心病患者中的变化,协助临床决策。方法收入64例糖尿病肾病合并冠心病患者及57例糖尿病肾病但无明确冠心病依据的患者,同时收入54例健康志愿者,以ELISA法检测分析其血浆中高敏C反应蛋白及巨噬细胞移动抑制因子的变化。结果糖尿病肾病合并冠心病组患者血浆hsCRP水平(9.93±2.58)mg/L及MIF水平(23.61±6.64)μg/L高于无明确冠心病依据的患者[hsCRP(7.37±1.32)mg/L,MIF(15.56±3.70)μg/L],差异有统计学意义(P均<0.05),两组患者血浆hsCRP及MIF水平又均显著高于对照组[hsCRP(3.51±2.00)mg/L,MIF(9.57±1.25)μg/L]。结论检测糖尿病肾病患者血浆hsCRP及MIF,可能有助于鉴别糖尿病肾病患者有无合并冠心病的危险。Objective To explore the relationship between the level of plasma high-sensitivity C-reactive protein （hsCRP） and macrophage migration inhibitory factor （MIF） in patients with diabetes nephropathy （DN） and coronary heart disease （CHD） for the establishment of a database for clinical use. Methods 64 diabetes nephropathy patients with coronary heart disease and 57 diabetes nepbropathy patients without coronary heart disease were enrolled into the study. 54 healthy volunteers were enrolled as the control subjects. The levels of plasma hsCRP and MIF were determined by ELISA. Results The levels of plasma hsCRP （9.93 ± 2.58）mg/L and MIF （23.61 ± 6.64）μg/L in DN patients with CHD were significantly higher than the DN patients without CHD [hsCRP （7.37 ± 1.32）mg/L; MIF （15.56 ± 3.70）μg/L]. The levels of plasma hsCRP and MIF in these two groups were significantly higher than the control group [hsCRP （3.51 ± 2.00）mg/L; MIF （9.57 ± 1.25）μg/L]. Conclusion The levels of plasma hsCRP and MIF in DN patients with CHD were significantly higher than the control and DN without CHD group. Detection of hsCRP and MIF may help the medical professionals to identify the high risk DN patients with CHD and to provide clinical evidence for reasonable PCI.

关 键 词：糖尿病肾病 冠心病 高敏C反应蛋白 巨噬细胞移动抑制因子 

分 类 号：R587.1[医药卫生—内分泌] R692[医药卫生—内科学]