血脉通颗粒对颈动脉粥样硬化的临床与实验研究  

The Clinical and Empirical Study of Xuemaitong Granula on Carotis Artherosclerosis

作　　者：张斌霞[1] 张亦民 曾晓惠 王紫逸 薛蕾 

机构地区：[1]南京中医药大学 [2]常州中医医院心内科,江苏常州213003

出　　处：《河南中医学院学报》2009年第3期40-43,共4页Journal of Henan University of Chinese Medicine

基　　金：江苏省常州市科技局科研基金项目(编号:CS2004216)

摘　　要：目的:探讨血脉通颗粒干预颈动脉粥样硬化症(CAS)的作用机理。方法:①临床研究:将77例CAS的患者随机分成治疗组(45例,血脉通颗粒)和对照组(32例,辛伐他汀),疗程0.5a,观察治疗前后血脂、超氧化物歧化酶(SOD)、丙二醛(MDA)、基质金属蛋白酶(MMP-1)的变化情况;②动物实验:用高脂饲料加空气干燥术制作家兔CAS模型,分成治疗组(血脉通大、中、小剂量组)和对照组(辛伐他汀),干预84d后,观察各组家兔血脂、血清循环内皮细胞(CEC)、血清基质金属蛋白酶-1(MMP-1)、MMP-9和基质金属蛋白酶组织抑制因子-1(TIMP-1)的变化。结果:临床治疗组治疗后TG、ox-LDL、LPa、MDA、MMP-1均有明显降低,SOD、HDL-C升高。实验发现血脉通颗粒可调节家兔血脂、降低CEC、MMP-1、MMP-9并升高其TIMP-1的水平。结论:血脉通颗粒可有效调控血脂,保护血管内皮细胞,稳定颈动脉粥样硬化斑块。Objective ： to approach the mechanism of action of Xuemaitong granula to treat carotis artherosclerosis. Methods ： 1. clinical study ： 77 cases of carotis artherosclerosis were randomly divided into treatment group（45 eases treated in Xuemaitong granula） and control group（32 cases treated in Simvastatin） , the course of treatment was 6 months. The blood fat, SOD, MDA and matrix metallo-proteinase were observed before and after treatment. 2. animal experiment： the rabbit CAS model were induced by high fat animal feeds and air drying. The animal were divided into treatment group（ Xuemaitong granula large, middle and small） and control group （Simvastatin）. The rabbit＇ s blood fat, CEC, MMP - 1, MMP -9 and TIMP - 1 were observe after treating 12 weeks. Results： the TG,ox - LDL, Lpa,MDA and MMP - 1 were obviously cut down and SOD and HDL - C were step up after clinical treatment. The animal experiment showed that the Xuemaitong granula had the function to regulate the rabbit＇ s blood fat and cut domn the CEC, MMP - 1 and MMP - 9 and raise the TIMP - 1 level. Conclusion ： Xuemaitong granula have the effect to control the blood fat, protect vascular endothelial ceil and stabilize the carotis artherosclerosis plaque.

关 键 词：颈动脉粥样硬化 血脉通颗粒 基质金属蛋白酶 TIMP-1 

分 类 号：R543.5[医药卫生—心血管疾病] R285.5[医药卫生—内科学]