2型糖尿病患者血清低密度脂蛋白免疫复合物的检测及临床意义  

Low-density lipoprotein immune complexes in patients with type 2 diabetes

作　　者：王雪琴[1] 崔世维[2] 金艳[1] 陶国华[1] 陈金锋[1] 吴刚[1] 

机构地区：[1]江苏省南通大学临床医学院第二附属医院内分泌科,226001 [2]南通大学临床医学院第一附属医院

出　　处：《中华全科医师杂志》2009年第6期407-409,共3页Chinese Journal of General Practitioners

基　　金：基金项目：江苏省南通市卫生局项目编号（W0410）

摘　　要：采用ELISA法测定102例2型糖尿病（T2DM）患者（其中54例合并大血管病变）、45例大血管病变患者及30例正常对照者的血清低密度脂蛋白免疫复合物（LDL-ICs）浓度。T2DM及大血管病变患者血LDL—ICs浓度均高于正常对照者，糖尿病合并大血管病变者高于单纯糖尿病、单纯大血管病变患者；血清LDL-ICs浓度与体重指数、血糖化血红蛋白、血压、总胆固醇、甘油三酯水平呈正相关，与高密度脂蛋白胆固醇水平呈负相关，与低密度脂蛋白胆固醇水平无相关性。LDL-ICs、血压、糖化血红蛋白是糖尿病大血管病变的危险因素。This study was designed to observe the clinical value of low-density lipoprotein immune complexes （LDL-ICs） in patients with type 2 diabetes mellitus （T2DM）. Fifty-four patients with type 2 diabetes ＋maeroangiopathy （DM-MA group）, 48 patients with type 2 diabetes （DM group）, 45 patients with maeroangiopathy （MA group）, and 30 normal controls （NC group） were enrolled. LDL-ICs levels in the DM-MA group were significantly higher than those in the other three groups. The levels of LDL-ICs in the MA group were higher than those in the NC and DM groups. There was a significant difference in LDL-ICs between the DM and NC groups. LDL-ICs levels were positively related with body mass index （ BMI）, glycosylated hemoglobin Ale（HbAlc）, blood pressure, total cholesterol, and triglyceride. There was no significant relationship between low-density lipoprotein cholesterol and LDL-ICs. A significantly negative correlation was recorded between high-density lipoprotein cholesterol and LDL-ICs. Our study suggests that LDL-ICs, blood pressure, and HbAlc may be risk factors of macroangiopathy in type 2 diabetic patients.

关 键 词：2型糖尿病 患者 脂蛋白类 LDL 

分 类 号：R446[医药卫生—诊断学] R587[医药卫生—临床医学]