脂质代谢、尿酸与突发性聋的关系  

Relationship between lipid metabolism,uric acid and sudden sensorineurol hearing loss

作　　者：朱文燕[1] 佘万东[1] 戴艳红[1] 高下[1] 倪容生[1] 

机构地区：[1]南京医科大学附属鼓楼临床医学院耳鼻咽喉头颈外科,南京210008

出　　处：《山东大学耳鼻喉眼学报》2009年第2期42-44,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：南京市医学科技发展项目(YKK05098)

摘　　要：目的探讨突发性聋与血清脂质代谢、血尿酸之间的关系。方法回顾性分析突发性聋住院患者100例的病史特点、血液学检查和影像学检查结果,检测其血清中甘油三酯、胆固醇、高密度胆固醇、低密度胆固醇、载脂蛋白AI、载脂蛋白B、血尿酸的含量。结果突发性聋组高密度胆固醇低于对照组,血尿酸值高于对照组,且差异有统计学意义(P<0.05),各年龄组之间的高密度胆固醇、尿酸值差异无统计学意义(P>0.05)。两组之间的甘油三酯、胆固醇、低密度胆固醇、载脂蛋白AI、载脂蛋白B值均差异无统计学意义。结论高密度胆固醇下降、尿酸代谢紊乱是突发性聋发生的危险因素。Objective To explore the relationship between changes of serum lipid metabolism, uric acid and sudden sensorineurol heating loss（SSNHL）. Methods The senun levels of triglyceride（TG）, cholesterol（CHO）, high density lipoprotein-cholesteml（HDL-CH）, low density lipopmtein-cholesteml（LDL-CH）, apolipoprotein AI（Apo AI）, apolipoprotein B （Apo B）and uric acid（UA） in 100 patients with sudden sensorineurol heating loss and 56 controls were determined. Results The serum levels of high lipoprotein-cholesterol were significantly decreased （ P 〈 0.05） and uric acid significantly increased （ P 〈 0.05） in the sudden sensorineural hearing loss group in comparison with the control group. There were no significant differences of high lipopmtein-cholesteml or uric acid in any age-group, also there were no significant differences in levels ofTG, CHO, LDL-CH, ApoAI and ApoB between the sudden sensorineural hearing loss groups and the control groups（ P 〉 0.05）. Conclusion Metabolic disturbance of serum lipids and uric acid in patients with sudden sensorineurol hearing loss may be related to the etiology of sudden sensorineural hearing loss.

关 键 词：突发性聋 脂质 尿酸 年龄 

分 类 号：R764.4[医药卫生—耳鼻咽喉科]