柔肝冲剂抗肝纤维化作用的实验研究  

EXPERIMENTAL STUDY ON THE ANTAGONISTIC EFFECT OF NOURISHING LIVER INFUSION ON RAT'S HEPATIC FIBROSIS

作　　者：王灵台[1] 高月求[1] 陈建杰[1] 张晓一[1] 

机构地区：[1]上海中医药大学附属曙光医院,上海200021

出　　处：《中国中医药科技》1998年第3期139-141,共3页Chinese Journal of Traditional Medical Science and Technology

摘　　要：本文旨在探讨柔肝冲剂抗肝纤维化的作用机制,采用二甲基亚硝胺(DMN)染毒制作肝纤维化大鼠模型,观察柔肝冲剂的抗肝纤维化作用。结果表明柔肝冲剂对肝纤维化大鼠有明显改善作用,使ALT、AST明显降低(P<O.05);对于各肝纤维化指标HA、PCⅢ、TC、LN均有明显减轻作用,与对照组及正常组比较均无明显差异(P>0.05);病理学改变冲剂组与秋水仙碱组无明显差异,较模型组有显著改善。免疫组化观察两用药组较模型组各型胶原为少。由此证明柔肝冲剂确具抗肝纤维化作用,其机理与保护肝细胞,抑制肝内胶原生成,促进胶原纤维降解等作用有关。In order to inquire the mechanism of antagonistic effect of nourishing liver infusion on hepatic fibrosis which the model was induced by Dimethynitrosamine (DMN). The results showed that nourishing liver infusion could significantly improve rat' s hepatic fibrosis, lower level of ALT and AST ( P > 0.05 ) , abate the changes ot HA, PC HI , TC, LN which represent hepatic fibrosis indexes. There was no difference between treatment group and normal (P > 0. 05 ) . The pathologic changes ot infusion group was slighter than that of model group, there was no difference between infusion group and western medicine group in histologic structure by optical microscope examination. the deposition of collagen types 1 , IK , IV , IV and laminin decreased more obviously than that of model group. All these indicated that nourishing liver infusion have the antagonistic effect on hepatic fibrosis, the mechanism was correlation to protecte hepatic cells, inhibite the formation of collagen and promote the degradation of collagen

关 键 词：肝疾病 中医药疗法 柔肝冲剂 病理学 

分 类 号：R259.752[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]