ABCG2蛋白及其在干细胞与肿瘤化疗耐药中的作用  

ABCG2 transporters and its role in stem cell and tumor chemotherapy resistance

作　　者：徐静(综述)[1] 崔毓桂(审校)[1] 刘嘉茵(审校)[1] 

机构地区：[1]南京医科大学第一附属医院生殖医学中心,210029

出　　处：《国际肿瘤学杂志》2009年第4期251-254,共4页Journal of International Oncology

基　　金：国家重点基础研究发展计划项目（2007CB948100）;教育部“长江学者和创新团队发展计划”项目（IRT0631）

摘　　要：三磷酸腺苷结合盒超家族G成员2（ABCG2）基因定位于4q22，以同源二聚体形式执行完整转运功能，在保护细胞及机体免受各种内外源物质伤害等方面起着重要作用，其功能发挥受自身结构、机体微环境及性激素等多种因素的影响。它参与了侧群（SP）干细胞表型形成，还与肿瘤的化疗耐药及肿瘤的发生密切相关。ATP-binding cassette superfamily G member 2 （ABCG2） gene resides on chromosome band 4q22. ABCG2 is a complete-transporter in homo-dimer form and is believed to play a major role in protecting cells and human body from exogenous and endogenous toxins. The function of ABCG2 is influenced by several factors such as the structure of itself,internal environment and sex hormones. ABCG2 participates the formation of side population stem cells phenotype, and is thought to relate with the multi- drug resistance of tumors and tu- morigenesis.

关 键 词：ATP结合匣式转运子 干细胞 肿瘤 抗药性 

分 类 号：R979.1[医药卫生—药品] R329.2[医药卫生—药学]