30年队列研究:接触石棉粉尘与石棉肺发病的剂量-反应关系  被引量:8

30 YEARS FOLLOW UP STUDY:THE DOSE-RESPONSE RELATIONSHIP OF ASBESTOS EXPOSURE AND ASBESTOSIS

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作  者:邓茜[1] 兰亚佳[1] 王绵珍[1] 

机构地区:[1]四川大学华西公共卫生学院职业卫生教研室,成都610041

出  处:《现代预防医学》2009年第11期2027-2028,2032,共3页Modern Preventive Medicine

摘  要:[目的]探讨温石棉加工工人接触石棉粉尘量与石棉肺发病的剂量-反应关系。[方法]采用固定队列研究方法。研究队列为388例男性石棉工人,入列条件为1972年1月1日工资在册,工龄满1年,没有明显心肺疾患者,追踪30年(1972~2002)记录接尘工人的职业史、体检史。收集工厂历年粉尘浓度检测数据。累积接尘量由接触浓度与时间相乘所得,以寿命表法建立石棉尘质量浓度的剂量患病概率直线回归方程式。[结果]工人累计接尘量与累计发病率之间有明显的剂量-反应关系(r=0.993,P﹤0.000),按1%石棉肺患病率、工人40年工作年限计算,预测石棉尘质量浓度应低于3.9mg/m3。[结论]现行国家石棉粉尘卫生标准是合理、安全的。[Objective] To learn the dose-response relationship of asbestosis incidence in the asbestos workers. [Methods] A fixed prospective cohort was established. 338 male exposed workers employed at least over one year in asbestos plant in Jan 1, 1972 were as study cohort. Collected the asbestos dust concentration records of all workplaces and the incidence of asbestosis during 30 years.The amount of accumulative exposure amounted to concentration multiplied with exposure time. The dose-response relationship between asbestos and asbestosis incidence was established by the method of life table. [ Results] The maximum allowable dust concentration of asbestos dust was predicted as 3.9mg/m^3 according to the presumption that the workers would work for 40 years and the incidence of asbestosis would be controlled under 1%. [Conclusion] The present hygienic standard of asbestos dust (MAC) in our country is reasonable.

关 键 词:石棉工人 石棉肺 剂量-反应关系 

分 类 号:R135.2[医药卫生—劳动卫生]

 

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