布托啡诺、舒芬太尼预防气管插管时心血管反应的临床效果比较  

Clinical effect of Butorphanol and Sufentanil on prevent cardiovascular responses to tracheal intubation

作　　者：段立杰[1] 张蕊[1] 高洁[1] 卢春媛[1] 陈宁[1] 

机构地区：[1]武警医学院附属医院麻醉科,天津300162

出　　处：《武警医学院学报》2009年第6期530-532,共3页Acta Academiae Medicinae CPAPF

摘　　要：【目的】比较布托啡诺和舒芬太尼两药用于全麻诱导时对血流动力学的影响，观察评价布托啡诺预防全麻诱导气管插管反应的临床效果。【方法】60例ASAⅠ-Ⅱ级行全麻气管插管择期手术的患者，随机分为两组（n=30）：布托啡诺组（B组）和舒芬太尼组（S组），观察并记录诱导前、诱导后2、4、6min和插管后即刻的心率和血压，行气管插管时患者的反应等。【结果】布托啡诺静注2、4、6min后血压、心率与注药前相比无显著差异性（P〉0．05）；舒芬太尼静注2、4、6rain后血压、心率下降明显（P〈0．05）；插管后即刻：B组较诱导前血压、心率无显著差异性（P〉0．05）；S组较诱导前血压心率有显著差异性（P〈0．05）。插管后B组与S组之间血压心率变化幅度有显著差异性（P〈0．05）。【结论】布托啡诺用于全麻诱导可有效的抑制气管插管时的心血管反应，因此认为布托啡诺可全麻诱导中进行选择使用。[Objective] To compare the different of Butorphanul and Sufentanil on hemodynamics, and to evaluate the clinical effect of Butorphanol on prevention from intubation- induced stress response. [Methods] PSixty patients, who were undergoing selective surgery, ASA Ⅰ-Ⅱ, were randomly devided into two groups （ n= 30） ： group Butorphanol （B） and group Sufentanil （S） . Group B butorphanol 30μtg/kg were given intravenously, Group S Sufentanil 0.2 Ⅰ-Ⅱg/kg were given intravenously, then Midazolam, Etomidate and Rocuronium were followed, at 2 （ T2） 、 4 （ T3 ） 、 6 （T4） minutes later respectively before anesthesia intubation. Meanwhile, blood pressure （BP）, heart rate （HR） and patients＇ response were recorded at before induction （T1）, T2, T3, T4 and after induction （Ts） . [Results] There was no different in BP and HR in group B at T2, T3 and T4 （P 〉 0.05）, however in group S both of them decreased significantly at T2 、 T3 and T4 （ P 〈 0.05） . Moreover in group B there was no difference in BP and HR at T5 （ P 〉 0.05）, in group S HR decreased significant at T5 in comparison with it at T1. [Conclusions] Butorphanol could inhibit the response of anesthesia induction effectively and it was concluded that Butorphanol could be used in anesthesia induction safely.

关 键 词：布托啡诺 舒芬太尼 全身麻醉 心血管反应 

分 类 号：R971.2[医药卫生—药品]