36例慢性皮肤溃疡创面阴沟肠杆菌药敏分析  

Drug Sensitivity Analysis of Enterobacter Cloacae in 36 Cases of Chronic Skin Ulcer Infection

作　　者：何仁亮[1] 刘英祥[2] 吴见欢 

机构地区：[1]广东省中山市黄圃人民医院皮肤科,528429 [2]广东省中山市黄圃人民医院外科,528429 [3]广东省中山市黄圃人民医院检验科,528429

出　　处：《中华全科医学》2009年第6期572-573,共2页Chinese Journal of General Practice

摘　　要：目的分析慢性皮肤溃疡创面阴沟肠杆菌对临床常用抗生素的耐药情况。方法对从慢性皮肤溃疡创面分离出的36株阴沟肠杆菌采用美国DADE公司生产的Microscan半自动微生物分析系统,采用Microscan Autoscan-4PC20快速革兰阴性鉴定板,鉴定出细菌。采用Microscan Autoscan-4PC20革兰阴性细菌药敏卡片,得出药敏的敏感程度。结果36例慢性皮肤溃疡患者对阿莫西林/棒酸、氨苄西林、头孢西丁、头孢噻吩耐药率为100%,对亚胺培南敏感率为100%,对阿米卡星敏感率72.4%,对头孢他定敏感率63.8%,对复方新明敏感率为41.7%,对其他多种抗生素呈现高度耐受。结论阴沟肠杆菌对临床常用抗生素药物具有高耐药率和高耐药水平,多重耐药现象较普遍,临床可把喹诺酮类抗生素和阿米卡星作为临床首选;也可以选用头孢他啶和复方新明。亚胺培南是对其最稳定、最可靠的敏感药物,可用于严重病例的治疗。Objective To investigate the drug resistance of enterobacter cloacae to common antibiotics in chronic skin ulcer infection. Methods 36 strains of enterobacter cloacae were collected from in-hospitals from Mar 2006 to Mar 2008. Drug sensitive test was performed with Microscan method and analyzed with Microscan Autoscan-4 PC20. Results Among 36 cases,the rate of resistance to amoxicillin, ampicillin, cefoxitin, cephalothin were 100% , to imipenem was 100% , to amikacin was 72.4%, to ceftazidime was 63.8% ,to sulfamethoxazole compound was 41.7% ,and showed high resistance to other kings of antibiotics. Conclusion The enterobacter cloacae has higher resistance to common antibiotics is in chronic skin ulcer infection. Quinolones and amikacine were first choice to treat the infections due to enterobacter cloacae, imipenem may be considered for critical patients.

关 键 词：阴沟肠杆菌 医院感染 药物敏感试验 耐药性 

分 类 号：R754[医药卫生—皮肤病学与性病学]