救脑宁注射液对实验性脑出血大鼠脑水肿及脂质过氧化的影响  

Effects of Jiunaoning Injection on Cerebral Edema and Lipid Peroxidation in Rats with Experimental Cerebral Hemorrhage

作　　者：黄世敬[1] 黄启福[1] 孙塑伦[1] 王永炎[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《北京中医药大学学报》1998年第2期38-40,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金："九五"国家科技攻关课题

摘　　要：在大鼠脑内注入自体血凝块造成大鼠脑内血肿模型，观察救脑宁注射液作用。结果：模型大鼠造模后１ｄ脑系数、脑组织含水量升高，第３ｄ达高峰，第７ｄ开始下降，但仍高于对照组；脑血管通透性升高与脑水肿变化相一致，并发现脑组织丙二醛（ＭＤＡ）升高、ＳＯＤ活性下降。救脑宁注射液、血塞通注射液均可不同程度降低脑系数和脑组织含水量，降低脑血管通透性及脑组织内ＭＤＡ含量，提高ＳＯＤ活性，但以救脑宁注射液效果更为明显。Bat intracerebral Hematoma model was induced by injecting autoblood clots of a rat into its brain in order to observe the effects of Jiunaoning injection on cerebral coefficient,cerebral water content,cerebrovascular permeability,cerebral MDA content,and cerebral SOD activity.After being injected autoblood clots,the cerebral coefficient and cerebral water content of the rats in model group increased on the first day,reaching to their climax on the third day and decreasing on the seventh day,but still higher compared with control group.It was also found that the increase of cerebrovascular permeability was correspondent with the seriousness of cerebral edema,MDA content increased and SOD activity decreased.Both Jiunaoning injection and Xueasaitong injection could decrease to some degree,the cerebral coefficient,cerebral water content,cerebrovascular permeability and MDA content,and increase SOD activity,but Jiunaoning injection had better effects.

关 键 词：脑出血 脑水肿 中医药疗法 救脑宁注射液 SOD 

分 类 号：R277.733.4[医药卫生—中医学]