罗库溴铵用于梗阻性肝胆疾病小婴儿的肌松效应  

Pharmacodynamics of rocuronium in infants with obstructive jaundice

作　　者：周志坚[1] 王炫[1] 张学锋[1] 

机构地区：[1]上海复旦大学附属儿科医院麻醉科,201102

出　　处：《临床麻醉学杂志》2009年第5期401-402,共2页Journal of Clinical Anesthesiology

摘　　要：目的研究单次插管剂量罗库溴铵对梗阻性肝胆疾病小婴儿的肌松效应。方法年龄1～4个月,无神经肌肉疾病、肾功能正常的小婴儿30例均分为肝胆疾病组(A组)和无肝胆疾病对照组(B组)。两组均以丙泊酚2mg/kg、芬太尼3μg/kg诱导,继以罗库溴铵0.6mg/kg单次剂量静脉注射。加速度仪监测拇内收肌的单刺激收缩反应,观察其起效时间、无反应时间、临床时效和恢复指数。结果A组起效时间为(81±35)s,长于B组的(51±28)s(P<0.05);两组无反应时间、临床时效、恢复指数差异无统计学意义。结论在梗阻性肝胆疾病婴幼儿,罗库溴铵起效时间延长。Objective To investigate the pharmacodynamics of rocuronium in infants with obstructive jaundice. Methods Thirty infants aged 1 to 4 months without neuromuscular diseases or renal dysfunction were divided into two groups with 15 cases each. The patients in group A were diagnosed with biliary atresia and scheduled for the kasai operation, and those in group B were with normal liver function and scheduled for abdominal surgery as the controls. Anestheisa was induced with propofol 2 mg/kg and fentanyl 3 g/kg. Rocuronium 0. 6 mg/kg was given and neuromuscular block was recorded with acceleromyography. Results Comparing with group B, The onset time of rocuronium wars significantly longer in group A than that in group B[（81±35） s vs （51±28） s]（P〈 0. 05）. There were no significant differences between the two groups in the maximum depression time [（49±15） rain vs. （48±12） mini or the clinical duration of action[（76±20） min vs. （71±14） mini. Conclusion The onset time of rocuronium is prolonged in infants with obstructive jaundice.

关 键 词：罗库溴铵 神经肌肉阻滞 胆道闭锁 

分 类 号：R726.1[医药卫生—儿科]