VCAM-1表达在上下呼吸道一致性的研究  

Expression and significance of VCAM-1 in subjects with allergic inflammation of respiratory tract

作　　者：王袁园[1] 周明辉[1] 娄卫华[2] 

机构地区：[1]河南大学淮河医院耳鼻咽喉科,河南开封475000 [2]郑州大学第一附属医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2009年第11期506-507,512,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨血管内皮细胞黏附分子(VCAM-1)在呼吸道变应性炎症患者中的表达和意义。方法:将39名患有变应性鼻炎并哮喘的患者和21例仅患有变应性鼻炎的患者分成两组,取鼻腔黏膜和支气管黏膜进行活组织病理检查,并用免疫组织化学的方法对VCAM-1的表达进行检测。结果:变应性鼻炎并哮喘组支气管黏膜中嗜酸粒细胞数显著高于变应性鼻炎组(t=12.81,P<0.01),变应性鼻炎组鼻腔黏膜中VCAM-1阳性细胞比例与变应性鼻炎并哮喘组相比差异无统计学意义。变应性鼻炎并哮喘组支气管黏膜中VCAM-1阳性细胞比例显著高于变应性鼻炎组(t=9.43,P<0.01),变应性鼻炎并哮喘组支气管黏膜中VCAM-1阳性细胞比例和支气管黏膜嗜酸粒细胞数呈显著正相关(r=0.783,P<0.01)。结论:VCAM-1表达的上调,导致呼吸道变应性炎症的蔓延。Objective：To study the expression and significance of vascular cell adhesion molecule-1（VCAM-1） in subjects with allergic inflammation of respiratory tract. Method： Thirty-nine subjects with allergic rhinitis and asthma （allergic rhinitis and asthma group ）and twenty-one subjects with only allergic rhinitis （allergic rhinitis group） were divided into two group. Bronchial and nasal biopsy specimens were taken and were stained with HE. The expression of VCAM-1 in nasal and bronchial mucosa was detected by immunohistochemistry technique. Resuit：The amouts of eosinophils within bronchial mucosa of allergic rhinitis and asthma group were significantly higher than that of allergic rhinitisgroup（t=12.81 ,P〈0.01）. The difference of VCAM-1 expression between allergic rhinitis group and allergic rhinitis and asthma group was not statistically significant . The amouts of VCAM- 1 positive cell in bronchial mucosa of allergic rhinitis and asthma group were significantly higher than that of aller gic rhinitis group（t=9.43, P〈0.01）. The number of VCAM1 positive cells in bronchial mucosa was significantly positively correlated with the number of eosinophils in bronchial mucosa of allergic rhinitis and asthma group（r=0. 783,P〈0.01）. Conclusion：This study shows that upregulation of VCAM results in generalized airway inflammation in patients with allergic rhinitis.

关 键 词：血管内皮细胞黏附分子 变应性鼻炎 哮喘 免疫组织化学 

分 类 号：R392.11[医药卫生—免疫学]