苯扎贝特对实验性高脂血症鹌鹑的调血脂作用  

The Lipidregulating Effects of Bezafibrate on the Experimental Hyperlipdaemic Quails

作　　者：张陆勇[1] 刘晓东[1] 季慧芳[1] 谢林[1] 张锐[1] 谢文敏[1] 刘国卿[1] 

机构地区：[1]中国药科大学生理学教研室

出　　处：《中国药科大学学报》1998年第1期61-63,共3页Journal of China Pharmaceutical University

摘　　要：以实验性高脂血症鹌鹑为模型观察了苯扎贝特对大鼠及鹌鹑血清中血脂的影响。试验表明，苯扎贝特能显著降低实验性高脂血症鹌鹑的血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）和低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）水平，并能升高高密度脂蛋白胆固醇（ＨＤＬ－Ｃ），其作用呈剂量依赖性。苯扎贝特调脂作用优于安妥明。The effects of bezafibrate on serum lipids were studied in quails and rats with experimental hyperlipemia. The results showed that bezafibrate could significantly reduce serum cholesterol, triglyceride, and lowfdensity lipoproteincholesterol(LDLC) concentrations, and increase the highdensity lipoproteincholesterol (HDLC) concentration in a dosedependent manner. Bezafibrate was more effective than clofibrate on lowering serum TC, TG, LDL C, VLDLC, TC/HDLC, AI, and increasing serum HDLC.

关 键 词：苯扎贝特 高脂血症 降血脂药 实验药理 

分 类 号：R972.6[医药卫生—药品] R589.205[医药卫生—药学]