HepaSphere微球栓塞治疗高流量动静脉畸形  

Embolization of high flow arteriovenous malformations with HepaSphere microspheres

作　　者：杜玉清[1] 堀信一 周为中[1] 刘永娥[1] 

机构地区：[1]温州医学院附属第一医院,325000 [2]日本大阪门塔大厦IGT专科医院,598004

出　　处：《中华整形外科杂志》2009年第3期193-196,共4页Chinese Journal of Plastic Surgery

摘　　要：目的探讨HepaSphere微球血管内栓塞治疗高流量动静脉畸形（arteriovenous malformations，AVM）的疗效。方法HepaSphere微球吸水后膨胀变软、直径大小可控制。13例AVM患者采用HepaSphere微球血管内栓塞治疗，其中3例栓塞后联合手术治疗。随访3个月至3年，根据临床症状的改善情况和影像学检查资料评价疗效。结果13例共进行28次栓塞治疗，10例单纯栓塞、3例（2例颌面部、1例肺部AVM）栓塞后手术完全切除，弥漫性AVM多次栓塞后症状均有所改善。组织学显示HepaSphere微球充填血管导致血管腔阻塞，血管壁炎性反应轻微。结论HepaSphere微球血管内栓塞治疗高流量AVM安全有效，对弥漫性AVM需要联合多种方法治疗。Objective To determine the effect, safety, and feasibility of embolization of high flow arteriovenous malformations（AVMs） with HepaSphere microspheres. Methods HepaSphere particles swell by absorbing fluids and become soft and deformable with a precisely calibrated diameter. 13 patients with AVMs were treated by transarterial embolization with HepaSphere particles. 3 cases underwent a following AVMs resection surgery. The follow-up period was 3 months to 3 years. Symptoms improvement and image examination were studied. Results 28 transarterial embolizations were performed in 13 cases. The resection operation was performed in 3 cases after transarterial embolizations. The symptoms in diffused AVMs improved after several transarterial embolizations. Histologically, HepaSphere particles penetrated into the intralesional vessels and conformed to the vessel lumen, resulting in vessel occlusion. Minimal perivaseular reaction was observed. Conclusions Embolization of high flow AVMs with HepaSphere microspheres is safe and effective. Combined treatment is necessary for diffuse AVMs.

关 键 词：动静脉畸形 栓塞 临床分析 治疗方法 

分 类 号：R654[医药卫生—外科学]