某地区老年人血8—羟基鸟嘌呤(8-OH-dG)水平调查  

Survey of blood 8-OH-dG level in the elderly in China

作　　者：林春晓[1] 马文军[2] 文素娟 朱志良[1] 

机构地区：[1]深圳市宝安区疾病预防控制中心,广东深圳518101 [2]北京大学公共卫生学院,北京100191 [3]深圳市宝安区人民医院,广东深圳518101

出　　处：《中国热带医学》2009年第6期1094-1095,共2页China Tropical Medicine

基　　金：深圳市科技立项项目(200603293)

摘　　要：目的测定某地区老年人血中8—羟基鸟嘌呤(8-OH-dG)水平,了解其在老年人群中的分布。方法用Human-8-OH-dG酶联免疫试剂盒检测血中8-OH-dG水平。结果正常人群中老年人血8-OH-dG水平为(11.43±7.53)ng/mg,男性为(11.39±7.21)ng/mg,女性为11.48±8.00ng/mg,不同性别间没有显著性差异。按60～69岁、70～79岁和对照组(50岁以下)3个年龄组分层,男性、女性和全体人群中各年龄组间血8-OH-dG水平无显著性差异(P>0.05),但随着年龄增长血8-OH-dG水平有增高的趁势。结论该地区老年人血中8—羟基鸟嘌呤(8-OH-dG)水平男女性中位数分别为7.99ng/mg和7.38ng/mg;95%可信限其参考范围男性为0～28.68ng/mg,女性为0～27.83ng/mg。Objective To detect the level of 8-OH--riG in blood of the elderly. Methods The content of blood 8- OH-dG were determined by ELISA kits. Results The average level of blood 8-OH-dG of normal senile population was （11.43±7.53）ng/mg.There was no significant difference between males and females, and the levels were （11.39±7.21 ）ng/mg and 11.48±8.00ng/mg respectively. The level of blood 8-OH-dG showed increasing trend along with the increase of the age. Conclusions The median value of blood 8-OH-dG of elderly males and females were 7.99ng/mg and 7.38ng/mg.

关 键 词：8-羟基鸟嘌呤(8-OH-dG) 老年人 参考值范围 

分 类 号：R161.7[医药卫生—公共卫生与预防医学]