PMAA/HEC核-壳聚合物纳米微球对亚甲基蓝负载和释放行为研究  

Loading and release behavior of PMAA/HEC core-shell polymeric nanoparticles with methylene blue

作　　者：毛章卓[1] 张幼维[1] 赵炯心[1] 吴承训[1] 

机构地区：[1]东华大学纤维材料改性国家重点实验室,上海201620

出　　处：《合成技术及应用》2009年第1期13-16,共4页Synthetic Technology & Application

基　　金：国家自然科学基金(20604006)

摘　　要：以羟乙基纤维素(HEC)和甲基丙烯酸(MAA)为原料,采用模板聚合方法制备了核-壳聚合物纳米微球。采用可见分光光度法,研究了该纳米微球对亚甲基蓝(MB)模型分子的负载容量及释放行为,并用粒径-电位仪和透射电镜对负载MB前后的纳米微球进行了表征。结果表明:纳米微球负载MB的容量主要依赖于微球中PMAA组分的含量以及介质的pH值;负载微球的释放速率具有pH依赖性,可以通过改变介质的pH值实现MB的可控释放。Using hydroxethyl cellulose （HEC） and methacrylic acid （MAA）, PMAA/HEC core-shell polymeric nanoparticles were prepared by template polymerization. Using visible absorption spectroscopy, the loading capacity of the nanoparticles with model molecule methylene blue （MB） and the release behavior of MB-loaded nanoparticles were investigated. Dynamic light scattering, electrophoretic light scattering and TEM techniques were used to trace the changes in the size, surface charge and morphology of the nanoparticles before and after loading MB. It was found that the MB-loading capacity of the nanoparticles mainly depended on the content of PMAA and pH value of the medium. The release of MB-loaded nanoparticles was pH-dependent and the controlled release of MB can be realized by changing the pH value of the medium.

关 键 词：聚合物纳米微球 亚甲基蓝 PH敏感性 可控释放 

分 类 号：O631.3[理学—高分子化学]