乳腺肿瘤超声造影灌注显像特征的初步观察  

Observation for the perfusion characteristics of breast lesions with contrast-enhanced ultrasound

作　　者：赵红佳[1] 董宝玮[2] 许荣[1] 黄松雄[1] 欧阳秋芳[1] 林晴[1] 王况[1] 

机构地区：[1]福建中医学院附属第二人民医院超声科,福建福州350003 [2]解放军总医院超声科,北京100853

出　　处：《中国医学影像技术》2009年第5期786-788,共3页Chinese Journal of Medical Imaging Technology

基　　金：福建省科技厅重点项目(2005Y029)

摘　　要：目的探讨乳腺肿瘤超声造影增强方式的特点及其对乳腺癌诊断的价值。方法应用SonoVue造影剂对76例患者的78个乳腺病灶(恶性47个,良性31个)进行超声造影检查,观察病灶的超声造影增强时相和增强方式。结果乳腺肿瘤超声造影时相可分为早(注入造影剂后1min)、中(注入造影剂1～4min)、晚(注入造影剂4～6min)三期。超声造影早期89.36%乳腺癌表现为不均匀"爪形"增强,而88.37%良性病灶表现为均匀点样增强,两组增强方式比较差异有统计学意义(χ2=41.83,P<0.01)。造影晚期89.36%乳腺癌可见少许造影剂滞留,而仅9.68%的良性结节于晚期可见造影剂滞留,两组造影剂廓清方式差异亦有显著统计学意义(χ2=48.59,P<0.01)。早期不均匀"爪形"增强对乳腺癌诊断的敏感性、特异性、准确性分别为89.36%、83.87%、87.18%,晚期造影剂滞留分别为89.36%、90.32%、89.74%。结论超声造影的增强模式对乳腺良、恶性肿瘤的诊断具有一定的价值。Objective To explore the enhancement pattern of breast lesions with contrast-enhanced ultrasound （CEUS） and its clinical efficacy in diagnosis of breast cancer. Methods CEUS was performed in 76 patients with 78 breast tumors （47 malignant and 31 benign） with bolus injection of Sonovue. The enhancement phase and enhancement pattern of breast lesions were observed. Results The perfusion course could be identified as early （0-1 min）, mid （1-4 min） and late （4-6 min） phases after SonoVue administration. In the early phase, 89.36% of malignant tumors showed claw-shaped enhancement, while 88. 37% of benign tumors showed homogeneous enhancement. There was a significant difference between the two enhancement patterns （X^2=41.83, P〈0.01）. In the late phase, contrast medium lingered in 89.36% of malignant tumors, while only in 9.68% of the benign tumors, the clearance of contrast medium was helpful in the identification of benign and malignant tumors （X^2= 48.59, P〈0.01）. As diagnosis indexes of breast cancer, the sensitivity, specificity and accuracy of claw-shaped enhancement in the early phase was 89.36%, 83. 87% and 87. 18%, respectively, while contrast medium lingered in the late phase was 89.36%, 90. 32% and 89.74%, respectively. Conclusion The enhancement pattern of breast lesion with CEUS is beneficial for diagnosing breast cancer.

关 键 词：超声检查 造影剂 乳腺肿瘤 增强方式 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]