脂质体作为抗癌药载体的应用进展  

Application of liposomes as carriers of anti-tumor drugs

作　　者：温志强[1] 桂双英[1,2,3] 王均[2] 陈维金[3] 

机构地区：[1]安徽中医学院药学院,合肥230031 [2]中国科技大学化学与材料科学学院,合肥230027 [3]安庆汇达丰药业有限公司,安庆246001

出　　处：《中国新药杂志》2009年第9期788-792,共5页Chinese Journal of New Drugs

基　　金：安徽省优秀青年科技基金计划项目(06043094);安徽省教育厅自然科学研究重点项目(KJ2007A121ZC)

摘　　要：脂质体是一种新型的药物传输系统。静脉注射未修饰脂质体包裹的药物主要被网状内皮系统(RES)的细胞摄取,可有效治疗与RES有关的疾病,但无特异靶向性。因此研究人员对脂质体进行了必要的修饰,在脂质双层上装上归槽装置或应用物理化学原理使其具有特异靶向性,以此提高其包裹药物的治疗指数和药物疗效,减小药物毒性。文中概述了脂质体药物传输系统的发展与基本特点,主要介绍了脂质体作为抗癌药物载体的研究进展。Liposomes are a new kind of the drug-delivery systems. Liposomes after intravenous injection are mainly extracted by the reticuloendothelial system （RES）. Therefore, liposomal agents can effectively treat the diseases related to the RES without specific targets. To increase they therapeutic index and been improved by locating the homing devices in the lipid layers or by applying the prineil~ In this paper, we sumnlarized the development in basic properties of the liposome drug-de the application of liposomes as carriers of in antitumor drugs.

关 键 词：脂质体 抗癌药 药物载体 

分 类 号：R944.9[医药卫生—药剂学] R979.1[医药卫生—药学]