米氮平与SSRIs类抗抑郁药对伴有性功能障碍的男性抑郁发作患者的对照研究  

A comparative study of mirtazapine and SSRI anti-depressants in outpatients with depressive episode of mood disorder

作　　者：过斌[1] 邸晓兰[1] 杨大中[2] 王宁[1] 陈大春[1] 赵萌[1] 马晓年[2] 

机构地区：[1]北京回龙观医院,北京100096 [2]清华大学附属玉泉医院,北京100049

出　　处：《中国新药杂志》2009年第9期806-809,814,共5页Chinese Journal of New Drugs

摘　　要：目的:观察米氮平与SSRIs类抗抑郁药对伴有性功能障碍的男性抑郁症患者的治疗效果和不良反应情况及性功能随药物治疗的变化情况。方法:采用开放性非随机对照研究方法,将120例伴有性功能障碍的男性门诊抑郁症患者分成2组,米氮平治疗组40例,SSRIs类抗抑郁药治疗组80例。使用汉米尔顿抑郁量表、不良反应观察量表及勃起功能指数国际自评问卷观察两治疗组的疗效、不良反应及性功能情况。两组共治疗12周,进行5次评定。结果:两组的显效率差异无统计学意义(P>0.05),治疗第8周末和治疗第12周末两组的HAMD得分差异有统计学意义(P<0.05),治疗第2,4,8和12周末两组的IIEF-5得分差异有统计学意义(P<0.05),药物不良反应发生率米氮平组少于SSRIs类抗抑郁药治疗组。结论:米氮平与SSRI类抗抑郁药有着同样肯定的疗效,在性功能不良反应发生方面少于SSRI类抗抑郁药。Objective： To observe the efficacy and adverse effects of mirtazapine and SSRI antidepressants, and their effects on sexual function in depression patients with sexual disorders. Methods： Outpatients with depression episode diagnosed according to the ICD-10 criteria （n = 120） were enrolled. The patients were treated with mirtazapine （n = 40） or SSRI antidepressants （n = 80） for 12 weeks. The therapeutic responses, adverse effects and sexual function were evaluated 5 times by scores of HAMD, TESS and IIEF-5. Results： The effective rates of 2 groups were not significantly different （P 〉 0.05 ）. However, HAMD scores were different in 2 groups at the ends of the 8th and 12th weeks after treatment （P 〈 0.05） ; IIEF-5 scores were also significantly different in 2 groups at the ends of the 2nd, 4th, 8th and 12th weeks after treatment （P 〈 0.05 ）. The adverse effects of mirtazapine were weaker than those of SSRI antidepressants. Conclusion： Mirtazapine is as effective as SSRI antidepressants in the treatment of depression episode, while the adverse effects and the effect on sexual function of mirtazapine are weak than SSRI antidepressants.

关 键 词：米氮平 SSRIs类抗抑郁药 性功能障碍 抑郁症 

分 类 号：R971.4[医药卫生—药品]