胆舒胶囊和软胶囊中薄荷脑的大鼠在体肠吸收动力学比较  

Comparison of menthol absorption kinetics in intestinal tract of rats between Danshu capsules and soft capsules

作　　者：花盈[1] 狄留庆[1] 谢新[1] 吴晓明[1] 

机构地区：[1]南京中医药大学中医药研究院,南京210029

出　　处：《中国新药杂志》2009年第9期827-829,849,共4页Chinese Journal of New Drugs

摘　　要：目的:比较胆舒软胶囊和胆舒胶囊中薄荷脑的大鼠在体肠吸收动力学。方法:采用大鼠在体肠吸收模型,以气相色谱法测定循环液中薄荷脑的浓度,比较在含相同薄荷脑浓度(0.3 g.L-1)时胆舒软胶囊和胶囊供试液中薄荷脑在整肠段的吸收速率及累计吸收率。结果:结扎胆管时,胆舒软胶囊和胆舒胶囊中薄荷脑的吸收速率常数(Ka)分别为(0.029±0.006)和(0.019±0.004)min-1;吸收半衰期(t1/2)分别为(25.09±5.53)和(37.16±8.97)min;2 h内薄荷脑的累积透过率分别为(94.24±0.33)%和(84.43±6.11)%。结论:将胆舒胶囊改制成软胶囊能加快薄荷脑在体内的吸收,使其迅速发挥疗效。Objective： To compare menthol absorption kinetics in intestinal tract of rats between Danshu capsules and soft capsules. Methods ： The model of in vivo intestinal absorption of rats was adopted ; the concentration of menthol in cycle-fluid was determined by GC. The absorption rate and accumulative absorption rate of whole intestines was compared between Danshu capsules and soft capsules containing the same concentrations of menthol （0.3 g·L^-1 ）. Results： After ligature of biliary ducts, the values of Ka of menthol in Danshu soft capsules and Danshu capsules were （0. 029± 0. 006） and （0. 019± 0. 004） min^-1 ; t1/2 were （25.09 ± 5.53 ） and （37. 16±8.97） min; accumulative absorption rate in 2h were （94.24±0.33）% and （84.43±6.11）%. Conclusion： To change the dosage form of Danshu capsules into Danshu soft capsules can speed up the absorption of the drug, which may improve its therapeutic effect.

关 键 词：胆舒软胶囊 胆舒胶囊 在体肠吸收 薄荷脑 

分 类 号：R943.1[医药卫生—药剂学] R285.5[医药卫生—药学]