氟尿嘧啶植入剂在蛋白变性剂乙酸中的行为研究  

Behavior of fluorouracil implants in protein-denaturant acetic acid

作　　者：王世亮[1,2] 王军[3] 尹情胜[2] 任翠丽[2] 冯梅[4] 

机构地区：[1]安徽职业技术学院,合肥230051 [2]合肥工业大学控释药物研究室,合肥230009 [3]天津大学化工学院,天津300072 [4]北京富地古医药研究所,北京100078

出　　处：《中国新药杂志》2009年第9期835-838,854,共5页Chinese Journal of New Drugs

摘　　要：目的:研究氟尿嘧啶植入剂与蛋白变性剂70%乙酸的相容性。方法:用HPLC法测定氟尿嘧啶在变性剂中的的稳定性、溶解度和植入剂在变性剂及大鼠体内的释放度并进行比较;显微镜观察植入剂在变性剂中的形态变化。结果:氟尿嘧啶在变性剂中稳定、溶解度约(30.37±0.38)g.L-1,植入剂在变性剂中表面隆起,按一级方程释药,释药速率较大鼠体内快。结论:氟尿嘧啶植入剂与70%乙酸相容性较好,可以配伍使用。Objective： To study the compatibility of the fluorouracil implants and protein-denaturant acetic acid （PDAA）. Methods： The stability, solubility and drug release quantity of fluorouracil implants in PDAA and the drug release quantity of fluorouracil implants in rats were determined by HPLC. The change in appearance of fluorouracil implants in PDAA was observed under the microscope. Results： At 37 ℃ in PDAA, the fluorouracil was stable after 360 h and the solubility of fluorouracil was about （30.37 ± 0.38） g. L^-1. The surface of fluorouracil implants was bulged in PDAA. The drug release character fitted the first-order equation both in vitro and in vivo. However, the drug release rate of fluorouracil implants in vitro was higher than that in vivo. Conclusion： The fluorouracil implants are compatible with PDAA and can be used in combination.

关 键 词：氟尿嘧啶 植入剂 蛋白变性剂 乙酸 缓释 局部化疗 

分 类 号：R943.3[医药卫生—药剂学] R979.1[医药卫生—药学]