盐酸戊乙奎醚的药动学研究进展  

Progress in pharmacokinetics of penehyclidine hydrochloride

作　　者：肖洪涛[1] 廖治[2] 莫正纪[3] 

机构地区：[1]四川省医学科学院.四川省人民医院药剂科,成都610072 [2]四川省医学科学院.四川省人民医院妇产科,成都610072 [3]四川大学华西药学院,成都610041

出　　处：《中国新药杂志》2009年第10期887-890,共4页Chinese Journal of New Drugs

摘　　要：盐酸戊乙奎醚是我国自主研发的一类抗胆碱新药,具有多方面药理作用,如戒毒、离体子宫松弛、肝损伤保护作用、肾损伤保护作用、前脑缺血再灌注损伤的保护作用,同时其临床应用也较多,用于胃肠道疾病、眼科疾病、呼吸道疾病、中枢神经系统疾病、麻醉、泌尿生殖道疾病、肾绞痛及膀胱刺激症、抗感染性休克、抗胆绞痛等。文中就其药动学研究做一综述,包括其拆分研究、动物体内的药动学、动物体内的分布、人体内的药动学,为其进一步开发提供参考。Penehyclidine hydrochloride, a novel medicine self-developed in China, and it has many pharmacology effects, e. g： refraining drug, isolated hysteranesis, protective effect of hepatic injury, protective effect of renal injury, protective effect of forebrain ischemia/reperfusion, and clinical applications. It was administrated to the patients with the diseases of gastrointestinal tract, ophthalmology, respiratory tract, central nervous system, and anesthesia, genitourinary tract, nephric colic, irritative symptoms of bladder, septic shock, biliary colic. In this paper the research progress on the pharmacokinetics of penehyclidine hydrochloride are reviewed, including its chiral separation, pharmacokinetics and distributions in animal, pharmacokinetics in human, in order to supply reference for its further exploitation.

关 键 词：盐酸戊乙奎醚 药动学 药物代谢 

分 类 号：R971.92[医药卫生—药品]