复方丹参滴丸对急性冠脉综合征患者经皮冠脉介入治疗后心肌微循环的研究  

Effect of compound Danshen dropping pills on myocardial microcirculation after percutaneous coronary intervention in patients with acute coronary syndrome

作　　者：范宝晶[1] 赵学忠[2] 

机构地区：[1]长春市中心医院心内科,长春130051 [2]吉林大学第一临床医院心血管内科,长春130021

出　　处：《中国新药杂志》2009年第10期903-906,共4页Chinese Journal of New Drugs

摘　　要：目的:运用心肌声学造影(myocardial contrast echocardiography,MCE)技术探讨急性冠脉综合征(acute coronary syndrome,ACS)患者经皮冠脉介入治疗(percutaneous coronary intervention,PCI)前后给予复方丹参滴丸后心肌微循环的改变。方法:选取急性心肌梗死(acute myocardial infarction,AMI)和不稳定心绞痛(unstable angina,UA)患者120例,分直接PCI、择期PCI和不稳定心绞痛PCI丹参滴丸治疗组,并为每组设立相应的对照组,每组20例,通过心肌声学造影技术观察复方丹参滴丸对心肌微循环的影响。结果:直接PCI、择期PCI和不稳定心绞痛PCI丹参滴丸治疗组患者心肌造影剂灌注的开始时间(AT)、灌注达峰时间(APT)均小于相应的对照组(P<0.05)。直接PCI、择期PCI和不稳定心绞痛PCI丹参滴丸治疗组患者心肌造影剂灌注的峰值强度(PI)、振幅(A)和振幅×曲线上升斜率(A×β)均大于相应的对照组(P<0.05)。结论:复方丹参滴丸能有效地改善急性冠脉综合征患者PCI术后心肌微循环障碍,对心肌具有一定的保护作用。Objective： To determine the effect of compound Danshen dropping pills （CDDP） on myocardial microcirculation after percutaneous coronary intervention （PCI） in patients with acute coronary syndrome. Methods： Patients with acute myocardial infarction or unstable angina （n = 120） were divided in to 6 groups： direct PCI ＋ CDDP group, direct PCI control group, elective PCI ＋ CDDP group, elective PCI control group, UA PCI ＋ CDDP group, and UA PCI control group （n=20 in each group）. The myocardial microcirculation was detected by myocardial contrast echocardiography in each patient. Results： AT and APT were shorter in three CDDP groups than in corresponding control groups. PI, A and A ×β were higher in three CDDP groups than in corresponding control groups. Conclusion： CDDP effectively improves myocardial microcirculation after percutaneous coronary intervention in patients with acute coronary syndrome.

关 键 词：复方丹参滴丸 急性冠脉综合征 经皮冠脉介入 心肌微循环 心肌声学造影 

分 类 号：R972[医药卫生—药品] R969.4[医药卫生—药学]