长期服用珍田胶囊对大鼠组织器官学变化的试验研究  

Effect of the Long-term Taking ZhenTian Capsule on Pathological Examinination in Rats

作　　者：王婷[1,2] 赵德明[1] 宋怀燕[2] 

机构地区：[1]中国农业大学国家动物传染性海绵状脑病实验室,北京100193 [2]中国医学科学院实验动物研究所,北京100021

出　　处：《中国畜牧兽医》2009年第5期194-198,共5页China Animal Husbandry & Veterinary Medicine

基　　金：中国科技部“兽医微生物菌种资源标准化”(2005KDA21205-7)

摘　　要：考察大鼠灌胃给予珍田胶囊后组织器官病理学变化。珍田胶囊以1.315、2.635、.26 g(生药)/kg剂量(分别相当于人临床剂量的13、26.1、52.2倍),对照组给予相同体积的蒸馏水;连续给大鼠灌胃180 d,逐日观察动物行为、外观及大小便。停药后继续观察4周,检测大鼠脏器系数,观察组织器官病理学变化。各给药组大鼠一般状况未见明显异常,内脏检查无病变。未观察到与受试药物相关的病理组织学改变。To study the pathological examination effect of ZhenTian capsule, the rats were orally given ZhenTian capsule for 180 days with the doses of 1. 315, 2.63 and 5.26 g （crude medicinal materials）/kg （13, 26.1 and 52.2 times of clinic does） while the control group was given the distilled water of the same volume and for 4 weeks of stopping administration. Meanwhile, rats＇ behavior and appearance were observed, and night shit and urine everyday amounts were measured, coefficient of the main organs and pathological examination of the rats were investigated. All the examinations and index are within the normal level. No significantly histological change related to visceral is observed.

关 键 词：珍田胶囊 长期毒性 大鼠 病理学 

分 类 号：S852.166[农业科学—基础兽医学]