老年冠心病患者冠脉支架置入后双联抗血小板治疗的临床评价  

Clinical Appraisal of Combined Application of Clopidogrel and Aspirin after Percutaneous Coronany Intervention in Old Man

作　　者：陈晖[1] 

机构地区：[1]郑州市中心医院心内科,郑州市450007

出　　处：《医药论坛杂志》2009年第9期8-10,共3页Journal of Medical Forum

摘　　要：目的评价老年冠心病患者择期经皮冠状动脉支架置入术后联合应用氯吡格雷和阿司匹林的有效性和安全性。方法随访因冠心病行支架置入术的老年患者(年龄>65岁)127例,所有患者术后连续服用氯吡格雷75mg/d和阿司匹林100mg/d,共12个月。观察患者服药期间主要心脏不良事件(包括死亡、非致死性急性心肌梗死、心绞痛复发、急性、亚急性或晚期血栓、靶血管重建、脑卒中)以及出血等不良事件的发生率。结果127例患者均无急性、亚急性血栓发生,晚期血栓发生率1.6%(2/127);无死亡;均未发生脑卒中;非致死性急性心肌梗死发生率1.6%(2/127);心绞痛复发发生率3.1%(4/127),靶血管重建发生率2.4%(3/127)。出血的发生率中严重者0.8%(1/127),轻微者3.9%(5/127)。结论老年患者冠状动脉支架置入术后联合应用氯吡格雷及阿司匹林可减少心血管事件的发生且不良反应少,临床实践证明安全有效。Objective To investigate the validity and safety of combined application of clopidogrel and aspirin after percutaneous coronary intervention in old man. Methods All 127 old patients （age 〉 65years ） after percutaneous coronary intervention operation were administered clopidogrel 75mg/day and aspirinl00mg/day for 12 months. Observe the patients taking medicine period main heart bad event （ including death, non - fatal myocardial infarction, subacute or later period thrombus, target vessel revascularization, apoplexy） as well as the hemorrhagia and so on bad event＇s formation rate. Results 127 patients not acute, subacute thrombus occurrence, later period thrombus 1.6% （2/127）; Does not have the death; Has not had the apoplexy; Nonfatal myocardial infarction 1.6% （2/127） ; The angina pectoris recurs 3.1% （4/127）, the target vessel revascularization 2.4% （3/127）. The hemorrhagic rate seriously 0. 8% （1/127）, bleeds slightly 3.9% （5/127）. Conclusion A long period of combined application of clopidogrel and aspirin arfer percutaneous coronary intervention in old man was safe and effective.

关 键 词：冠状动脉疾病 老年患者 血小板聚集抑制剂 血管重建术 

分 类 号：R541.4[医药卫生—心血管疾病]