不同时期分离的淋病奈瑟菌药物敏感性测定  

Study on Susceptibility of Neisseria Gonorrhoeae Isolated from Chengdu in Different Periods

作　　者：向辉[1] 雍刚[2] 叶梅君[1] 李绍兴[2] 周蓉[1] 廖巫山[2] 周启贵[2] 

机构地区：[1]华西医科大学公共卫生学院 [2]四川省皮肤病性病防治研究所

出　　处：《中华皮肤科杂志》1998年第3期166-167,共2页Chinese Journal of Dermatology

基　　金：四川省科委和四川省卫生厅基金共同资助

摘　　要：目的　了解淋病奈瑟菌对抗生素敏感性的变迁情况。方法　对门诊 1991年和 1996年各 10 0株标本进行了 12种抗生素最小抑菌浓度 (MIC)测定。同时对产青霉素酶株 (PPNG)和非产青霉素酶株 (non PPNG)的MIC值进行了比较。结果与结论　青霉素G、四环素等 6种抗生素MIC值 1996年与 1991年两者之间有显著性差异 (P <0 0 5或P <0 0 1)。其中MIC50 值变化较大的是青霉素G和氟哌酸 ,1996年比 1991年均增加 6 3倍。此外 ,PPNG株和nonObjective To study the changes of susceptibilities of Neisseria gonorrhoeae to antibiotics in Chengdu area. Methods The MIC values of 12 antibiotics to 100 strains in 1991 and 100 strains in 1996 were determined, and the MIC values to PPNG and non PPNG strains were also compared. Results and Conclusion The MIC values of 6 antibiotics (including penicillin G, tetracycline,etc.) to the isolates in different periods changed significantly (P<0.05 or P<0.01), and among them the values of MIC 50 of penicillin G and norfloxacin in 1996 had a 63 fold increase over those in 1991. Moreover, there was a difference in MIC values between PPNG and non PPNG strains.

关 键 词：淋病奈瑟菌 药敏性 分离 

分 类 号：R378.16[医药卫生—病原生物学] R969.4[医药卫生—基础医学]