中等强度跑台运动对大鼠缺血/再灌注心肌的保护作用  

Protective effect of medium intensity treadmill exercise on ischemic/reperfused myocardium in rats

作　　者：李文勇[1] 

机构地区：[1]安阳师范学院体育学院,河南安阳455002

出　　处：《山东体育学院学报》2009年第5期29-32,共4页Journal of Shandong Sport University

摘　　要：目的:探讨运动预适应(EP)对大鼠心肌相对缺血再灌注(I/R)损伤的延迟保护作用。方法:15只Wistar大鼠随机分为2组(每组15只):对照组、运动组,应用Langendorf离体心脏I/R模型,观察各组大鼠心脏再灌注期间心律失常的发生情况、LVDP及RPP恢复率及心肌梗死范围。结果:运动组大鼠LVDP(再灌注30,60 min)和RPP(再灌注20,30,60 min)恢复率高于对照组,心肌梗死范围显著低于对照组(P<0.01)。结论:中等强度跑台运动对大鼠心肌相对I/R损伤有明显的保护作用。Objective：To explore the delayed protection of exercise preconditioning from the relative myocardial ischemia＇ repefusion injury . Methods ： Thirty Wistar rats were randomly divided into 2 groups （ n = 15 respectively） ： control group, exercise group. The occurrence of arrhythmia, the recovery of LVDPand RPP, and infarct size were observed by using the Langendorf- ischemia/reperfusion model in isolated rat heart in vitro. Results ： Recovery rate of LVDP（on the 30th and 60th minute of reperfusion）and RPP（on the 20th, 30th and 60 minute of reperfusion）of EXE group were higher than those of control groups（ P 〈 0.05 ）, infarct size of EXE group was dramatically lower than that of control groups （ P 〈 0.01 ）. Conclusion ： Medium intensity treadmill exercise has obvious protection from the relarive myocardial ischemia - reperfusion injury.

关 键 词：中等强度跑台运动 缺血/再灌注 心肌保护 

分 类 号：G804.7[文化科学—运动人体科学]