血栓弹力图评价老年患者服用抗血小板效果的研究  

Evaluation of Inhibition of Different Antiplatelet Agents in old Patients by Thrombelastogram

作　　者：陈韦任[1] 樊瑾[1] 王曙霞[1] 刘剑锋[1] 

机构地区：[1]中国人民解放军总医院南楼心血管一科,北京100853

出　　处：《血栓与止血学》2009年第2期73-74,共2页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的血栓弹力图观察我院老年患者服用血小板后抑制率情况。方法检测我院住院和门诊48例老年人血栓弹力图测得AA和ADP途径诱导的血小板抑制率值,并将病人分成阿司匹林组、氯吡格雷组、阿司匹林+氯吡格雷组,与未服用阿司匹林+氯吡格雷组(对照组)26例进行比较。结果48例患者中,阿司匹林组AA诱导的血小板抑制率为86.6±21.2%,氯吡格雷组ADP诱导的血小板抑制率平均值为49.3±23.8%,阿司匹林+氯吡格雷组AA诱导和ADP诱导的血小板抑制率为分别91.8±12.8%和54.2±22.7%,血小板抑制率均显著高于对照组(P<0.01)。结论阿司匹林能起到很好的抗血小板作用,氯吡格雷稍差,同时服用阿司匹林和氯吡格雷能起到更强的抗血小板作用。Objective To detect the percentage clotting inhibition by the use of thrombelastogram in old patients with different forms of antiplatelet agents. Methods percentage clotting inhibition about 48 old patients which were divided into three groups. Group aspirin, clopidogrel and aspirin ＋ clopidogrel, contrast to control group. Results Platelet receptor inhibition in response to arachidonic acid （AA） in group aspirin was 86.6 ±21.2%, platelet receptor inhibition in response to adenosine diphosphate （ADP） in group clopidogrel was 49.3 ± 23.8%, AA and ADP in aspirin ＋ clopidogrel was 91.8 ± 12.8% and 54.2±22.7%, group aspirin,clopidogrel and aspirin ＋ clopidogrel significantly compared with control group （P 〈 0.01 ）. Conclusion Aspirin , clopidogrel and aspirin ＋ clopidogrel can all inhibit platelet aggregation definitely.

关 键 词：血栓弹力图 血小板抑制率 阿司匹林 氯吡格雷 

分 类 号：R973[医药卫生—药品]