肾脏切除术后大鼠脉搏波变化的分析比较研究  

Research of pulse wave's change of rats after kidney resection

作　　者：汪南玥[1] 于友华[1] 黄大威 闪增郁[1] 陈燕萍[1] 

机构地区：[1]中国中医科学院医学实验中心,北京100700 [2]贝尔实验室中国基础科学研究院,北京100080

出　　处：《中华中医药杂志》2009年第6期796-798,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家十一五科技支撑计划项目(No.2006BAI08B01-02);基本科研业务费课题项目(No.ZZ2006043)

摘　　要：目的:研究大鼠肾脏切除术后脉搏波的变化及其规律。方法:在麻醉状态下,采集大鼠双侧股动脉脉搏波后,进行一侧肾脏切除手术。待手术结束伤口痊愈后再次进行脉搏波的采集。选取周期长度出现最多的脉搏波做平均,然后用对应该周期长度的6次谐波做最小二乘回归,应用统计方法对所拟合平均波形的基波和各谐波的相位与振幅进行比较分析。结果:手术同侧的股动脉脉搏波的第3谐波振幅增强,对侧第1、2、3、4、5次谐波振幅增强,第1、2次谐波相位增大并具有规律性。结论:大鼠一侧肾脏切除术后其股动脉脉搏波上出现特征性改变,提示体表的动脉脉搏波可以反映机体内脏的变化,为中医脉诊方法提供了一定的科学依据和研究参考。Objective： To study the change rule of rats＇ pulse waves after kidney resection. Methods： To collect the pulse waves of femoral artery in each side of rats in Drugged state. Then do one-side kidney resection operation, after fully recover from it, collect the pulse waves again. To average the pulse waves in the same cycle length and then do the LSQ regression by 6 harmonics which are correspond with the cycle lengths, analyze the phase and the amplitude of vibration of fundamental wave and harmonics by statistical method. Results： The amplitude of vibration of the 3rd harmonics of pulse waves of femoral artery in the same side with operation and the amplitude of vibration of the 1st to 5th harmonics of pulse waves of femoral artery in the other side with operation has reinforced, the phase of the 1st and 2nd harmonics also have changed regularly. Conclusion： There＇re some regular changes in the pulse waves of rats after one-side kidney resection operation, which shows that the pulse waves of artery on the body surface can reflect the splanchnic changes. This research can offer some scientific foundation to the pulse-diagnosis in TCM.

关 键 词：肾脏切除大鼠 脉搏波 频谱分析 谐波 

分 类 号：R699[医药卫生—泌尿科学]