霉酚酸酯在肾移植受者的多剂量药代动力学研究  

Pharmacokinetics of Mycophenolate Mofetil Administered in Multiple Oral Dose in Renal Transplantation Recipients

作　　者：任斌[1] 李敏薇[1] 李碧虹[1] 许琼[1] 吴爱琴[1] 何秋毅[1] 陈孝[1] 

机构地区：[1]中山大学附属第一医院,广东广州510080

出　　处：《今日药学》2009年第5期20-22,共3页Pharmacy Today

基　　金：广东省医院药学研究基金(编号:200731)

摘　　要：目的研究肾移植受者口服多剂霉酚酸酯(MMF)后霉酚酸(MPA)的药代动力学特征。方法24例肾移植受者分为2组,口服MMF1.5g/d,于术后第7d、14d检测服药后不同时点静脉血MPA浓度,计算药动学参数。结果术后第7d、14dMPA峰浓度Cmax分别为(12.3±5.7)和(12.3±5.4)μg/ml(p>0.05);谷浓度C0分别为(0.7±0.5)和(1.8±1.0)μg/ml(P<0.05);Tmax分别为(1.5±0.9)和(1.3±0.6)h(P>0.05);AUC0-12h分别为(27.0±10.1)和(39.8±16.4)μg.h/ml(P<0.05);MRT0-12h分别为(3.2±0.8)和(4.0±0.6)h(P<0.05)。结论肾移植受者口服多剂MMF后,MPA在体内存在明显蓄积现象,需要对MPA进行血药浓度监测。Objective To study pharmacokinetics of mycophenolic acid （MPA） after Mycophenolate mofetil （MMF） was administered in mulpital oral dose in renal transplantation recipients. Methods 24 first renal allograft recipients were divided into 2 groups. All received a triple immunosuppressive regimen of MMF, cyclosporine （CsA） and corticosteroids. 9 samples of serum were drawn at the day 7 and day 14 after transplantation. MPA concentration was determinedby HPLC and MPA pharmacokinetic parameters were calculated. Results The main pharmacokinetic parametersof MPA at the day 7 and day 14 after transplantation were as follows： Cmax were （ 12. 3 ± 5.7 ） and （ 12.3 ± 5.4 ） μg/ml （ P 〉 0. 05 ） ; CO were （0.7±0.5） and （1.8 ±1.0）μg/ml （P〈0. 05）;Tmax were （1.5 ±0.9） and （1.3±0.6） h （P〉0.05）; AUC0-12hwere （27.0± 10.1） and （39.8 ± 16.4） μg · h/ml （P 〈0.05）;MRT0 - 12h were （3.2 ±0.8） and （4. 0 ± 0. 6）h（P 〈 0. 05 ）. Conclusion： The accumulation for MPA after MMF administered in muhipleoral dose in renal transplantation recipients was detected. MPA plasma concentration should be monitored in clinicalpractice.

关 键 词：霉酚酸 肾移植 药代动力学 

分 类 号：R971.4[医药卫生—药品]