叶下珠化学成分及其抗乙肝病毒活性的研究  

Studies on Chemical Constituents of Phyllanthus urinaria L. and its Antiviral Activity against Hepatitis B Virus

作　　者：仲英[1,2,3] 左春旭[1,2,3] 李风琴 丁杏苞[1,2,3] 姚庆强 吴克霞[1,2,3] 张琴冈 王志玉[1,2,3] 周玲 王菊[1,2,3] 兰静 王晓静[1,2,3] 

机构地区：[1]山东省医学科学院药物研究所 [2]济南市传染病医院 [3]山东医科大学

出　　处：《中国中药杂志》1998年第6期363-364,共2页China Journal of Chinese Materia Medica

摘　　要：对大戟科叶下珠属植物叶下珠的干燥全草进行了化学成分及其抗乙肝病毒活性的研究，共分得１１个化合物，其中２个新化合物为去氢诃子次酸甲酯、短叶苏木酚酸甲酯。通过抗病毒、抗乙肝表面抗原及保肝试验。s Studies on the chemical constituents of Phyllanthus urinaria and its antiviral activity against hepatitis B virus were completed. Eleven compounds have been isolated. Two of them are new compounds methyl ester dehydrochebulic acid and methyl brevifolin carboxylate. Antiviral experiments on HBsAg in vitro and liver damage caused by CCl 4 have shown that.Phyllanthus urinaria possesses antiviral activities against HBV.

关 键 词：叶下珠 化学成分 抗病毒 去氢诃子次酸 甲酯 

分 类 号：R284.1[医药卫生—中药学] R259.126.2[医药卫生—中医学]