活血潜阳方对高血压大鼠血压和左室心肌间质重构的影响  

Effects of Huoxue Qianyang Formula on Blood Pressure and Reconstitution of Interstitial Substance of Left Ventricular in Spontaneous Hypertension Rat

作　　者：青淑云[1,2] 符德玉[1] 杨秀青[1] 钱岳晟[3] 罗海明[1] 金露[1] 徐邦杰[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院心内科,上海200437 [2]武警8660部队医院内科,新疆伊宁835000 [3]上海市瑞金医院心内科,上海市高血压研究所,上海200025

出　　处：《辽宁中医药大学学报》2009年第6期244-246,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30572381)

摘　　要：目的:观察活血潜阳方对自发性高血压大鼠(SHR)血压和左室心肌间质重构的影响。方法:72只SHR随机分SHR对照组、活血潜阳方组、缬沙坦组及两药合用组。20只京都Wistar大鼠(WKY)作为正常对照组。治疗前测大鼠尾动脉收缩压(SBP)、舒张压(DBP);分别于治疗7周及14周后测定SBP、DBP和左心室重量指数(LVMI),光镜观察并计算胶原容积分数(CVF)。结果:SHR的SBP、DBP、LVMI和CVF均高于同龄WKY大鼠(P<0.05或P<0.01)。活血潜阳方治疗14周可抑制SHR的SBP、DBP增高(P<0.05或P<0.01),可降低SHR的LVMI和CVF(P<0.05或P<0.01),较7W效果更明显;活血潜阳方与缬沙坦合用治疗14周可进一步降低SHR的CVF(P<0.01)。结论:长疗程(14W)的活血潜阳方治疗具有缓和的降压作用,并改善心肌间质重构,可能是其逆转高血压左室肥厚的机制。Objective：To explore the effects of Huoxue Qianyang formula on blood pressure and reconstitution of left ventricular（LV）.Methods： Seventy-two SHRwere randomly devided into SHR control （SHR-C） group, Huoxue Qianyang formula （SHR-H） group, Valsartan （SHR-V） group and combination of Huoxue Qianyang formula and Valsartan （SHR-HV） group. Twenty Wistar-Kyoto （WKY） rats served for normal controls. The half of rats in every group were observed respectively for seven or fourteen weeks. Before and after treatment, the systolic and diastolic blood pressure （SBP, DBP） were measured. After different courses of treatment, left ventricular mass index （LVMI）, interstitial collagen volum fraction （CVF） were measured.Results： SBP,DBP,LVMI,CVF and fibroblast amount were higher in the SHR-C group than those in the WKY group. They were lower in SHR-H group than those in the SHR-C group, and the effects were more evidently after fourteen weeks than seven weeks after fourteen weeks. CVF in SHR-HV was the lowest in all SHR.Conclusion： Huoxue Qianyang formula can lower blood pressure of SHR gently, and ameliorate reeonstitution of interstitial substance of LV. It can be one of mechanism which Huoxue Qianyang formula reverse left ventrieular hypertrophy in essential hypertension.

关 键 词：活血潜阳方 高血压 左室肥厚 心肌间质重构 大鼠 

分 类 号：R259.441[医药卫生—中西医结合]