甲状腺功能亢进症患者血浆对氧磷酯酶1活性的测定  

Analysis of Paraoxonase 1 Activity in the Patients with Hyperhyroidism

作　　者：蒋兴亮[1] 凡瞿明[1] 张晓岚[1] 刘素兰[1] 张均[1] 王光华[1] 

机构地区：[1]川北医学院附属医院检验科,四川南充637000

出　　处：《华西医学》2009年第4期902-904,共3页West China Medical Journal

摘　　要：目的:探讨甲状腺功能亢进症(甲亢)患者血浆对氧磷酯酶1(PON1)活性变化以及与其它氧化应激指标的关系。方法:分别测定50名对照组和78例甲亢组空腹血浆中游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、PON1活性、超氧化物歧化酶(SOD)、丙二醛(MAD)、氧化低密度脂蛋白(ox-LDL)及血脂含量,并进行相关性分析。结果:甲亢患者血浆PON1活性(139±64)kU/L,ox-LDL(598.3±58.6)μg/L,MDA(15.11±3.26)μmol/L及SOD(80.2±25.3)NU/mL。对照组上述指标分别为:PON1(168±70)kU/L,ox-LDL(446.2±62.2)μg/L,MDA(10.02±3.00)μmol/L,SOD(92.9±26.9)NU/mL。血浆PON1和SOD活性显著低于对照组(P<0.01),ox-LDL和MDA水平显著高于对照组(P<0.01)。甲亢患者血浆PON1活性与SOD呈正相关(r=0.381,P<0.05),与ox-LDL、MDA呈负相关(r=-0.411,r=-0.445,P<0.01)。结论:甲亢患者血浆PON1活性显著降低,可能与氧化应激增强有关。Objective： To understand the PON1 （PON1） activity in the patients with hyperthyroidism, and the relationship between PON1 activity and other oxidative stress parameter. Methods： The fasting plasma levels of free triiodothyronine （FT3）, free thyroxin（FT4）, thyroid stimulating hormone （TSH）, PON1 activity, superoxide dismutase （SOD） and malondialdehyde （MDA）, oxidized low-density lipoprotein （ox-LDL） level and lipids levels in 50 normal controls and 78 hyperthyroidism patients were determined respectively. The correlation analysis were completed. Results： In hyperthyroidism patients plasma PON1, ox-LDL, MDA and SOD were （ 139±64） kU/L, （598.3±8.6）μg/ L, （15.11±3.26）μmol/L, （156.4±32.2）U/L, （80.2±25.3）NU/mL,respectively. In the normal control subjects PON1, ox-LDL, MDAand SOD were （168±70）kU/L, （446.2±62.2）μg/L, （10.02±3.00） μmol/L,（92.9±26.9）NU/mL, respectively. The plasma PON1 and SOD activity were significantly lower in hyperthyroidism patients than in the control subjects （P〈0.01）. The plasma MDA and ox-LDL levels were significantly higher in hyperthyroidism patients than in the control subjects （P〈0.01）. The analysis of linear correlation showed PON1 was positively correlated with SOD（r=0. 381, P〈0.05）, and negatively correlated with ox-LDL （r =-0. 411, r =-0. 445, P〈0.01）. Conclusion：Plasma PON1 activity was significantly decreased in patients with hyperthyroidism. Increased oxidative stress are associated with decreased PON1 activity in the hyperthyroidism state.

关 键 词：甲状腺功能亢进症 对氧磷酯酶1 丙二醛 超氧化物歧化酶 

分 类 号：R581.1[医药卫生—内分泌]