Synthesis and micellization behavior of stimuli-responsive polypeptide hybrid triblock copolymer  

作　　者：RAO JingYi ZHU ZhiYuan LIU ShiYong 

机构地区：[1]Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Soft Matter Chemistry, Department ofPolymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China

出　　处：《Chinese Science Bulletin》2009年第11期1912-1917,共6页

基　　金：Supported by the National Natural Science Foundation of China (Grant Nos.20534020, 20674079, and 20874092)

摘　　要：Polypeptide hybrid triblock copolymer, poly(L-glutamic acid)-b-poly(propylene oxide)-b-poly (L-glu-tamic acid) (PLGA-b-PPO-b-PLGA), was synthesized by the ring-opening polymerization of benzyl-L-glutamic N-carboxyanhydride (BLG-NCA) using poly(propylene glycol) bis(2-aminopropyl ether) as initiator, followed by the subsequent deprotection step. The obtained double hydrophilic triblock co-polymer exhibits "schizophrenic" micellization behavior in aqueous solution upon dually playing with solution pH and temperature. The multi-responsive micellization behavior of this polypeptide hybrid triblock copolymer has been thoroughly investigated by 1H NMR, laser light scattering (LLS), tempera-ture-dependent optical transmittance, and circular dichroism spectroscopy (CD).Polypeptide hybrid triblock copolymer, poly（L-glutamic acid）-b-poly（propylene oxide）-b-poly （L-glutamic acid） （PLGA-b-PPO-b-PLGA）, was synthesized by the ring-opening polymerization of benzyI-L- glutamic N-carboxyanhydride （BLG-NCA） using poly（propylene glycol） bis（2-aminopropyl ether） as initiator, followed by the subsequent deprotection step. The obtained double hydrophilic triblock co- polymer exhibits ＂schizophrenic＂ micellization behavior in aqueous solution upon dually playing with solution pH and temperature. The multi-responsive micellization behavior of this polypeptide hybrid triblock copolymer has been thoroughly investigated by 1H NMR, laser light scattering （LLS）, tempera- ture-dependent optical transmittance, and circular dichroism spectroscopy （CD）.

关 键 词：三嵌段共聚物 胶束化行为 混合 多肽 合成 温度依赖性 反应 雷电定位系统 

分 类 号：TQ423.12[化学工程] O632.13[理学—高分子化学]