还原型谷胱甘肽治疗恙虫病合并中毒性肝炎的临床观察  

Clinical Study on Reduced Glutathione in Treatment of Tsutsugamushi Disease Complicated with Toxic Hepatitis

作　　者：王轶[1] 方亮[1] 周艳[1] 厉新妍[1] 郭文[1] 

机构地区：[1]广东省广州市第一人民医院,510180

出　　处：《职业与健康》2009年第12期1337-1338,共2页Occupation and Health

摘　　要：目的观察在抗感染的同时采用还原型谷胱甘肽治疗恙虫病合并中毒性肝炎的临床疗效。方法将32例恙虫病合并中毒性肝炎患者随机分为2组,治疗组17例在抗感染及给予甘草酸二铵护肝降酶基础治疗上加用还原型谷胱甘肽,对照组15例仅予抗感染及甘草酸二铵护肝降酶。2组均治疗2周。结果治疗组加用还原型谷胱甘肽可使患者临床症状消失或明显改善,总有效率为88.2%,对照组为66.7%。肝功能各指标恢复正常或下降优于对照组。结论还原型谷胱甘肽治疗恙虫病合并中毒性肝炎疗效良好,安全性高。[ Objective ] To study the therapeutic effects of reduced glutathione combined with anti - infection therapy in treatment of tsutsugamusshi disease complicated with toxic hepatitis. [ Methods] 32 patients with tsutsugamusshi disease complicated with toxic hepatitis were randomly divided into the treatment group and the control group. The treatment group （ 17 cases ） received reduced glutathione injection on the basis of anti - infection therapy and diammonium glyeyrrhizinate injection which can protect liver and decrease enzyme. The control group （ 15 cases） was given anti -infection therapy and diammonium glyeyrrhizinate injection. The duration of therapy was 2 weeks in both groups. [ Results] The symptoms of the treatment group patients disappeared or improved obviously with extra reduced glutathione injection. The total effective rate of the treatment group was 88.2%, and that of the control group was 66.7%. All indexes of liver function in the treatment group recovered or decreased which better than that in the control group. [ Conclusion] Reduced glutathione is effective and safe for tsutsugamusshi disease complicated with toxic hepatitis.

关 键 词：还原型谷胱甘肽 恙虫病 并发症 中毒性肝炎 临床研究 

分 类 号：R513.2[医药卫生—内科学]