液基细胞学和高危人乳头瘤状病毒DNA检测对宫颈病变筛查的价值  

The Value of Thinprep Cytologic Test and High-risk HPV DNA Testing on Screening for Cervical Lesions

作　　者：邹叶青[1] 辛华[2] 刘川[1] 谭布珍[2] 

机构地区：[1]南昌大学第二附属医院分子重点实验室,南昌330006 [2]南昌大学第二附属医院妇产科,南昌330006

出　　处：《江西医学院学报》2009年第2期112-113,115,共3页Acta Academiae Medicinae Jiangxi

摘　　要：目的探讨液基细胞学(TCT)和高危人乳头瘤状病毒DNA(HR-HPV DNA)检测对宫颈病变筛查的价值。方法对南昌大学第二附属医院妇科门诊1682例宫颈炎患者进行TCT检查,并对其中TCT检查结果异常的患者行HR-HPV DNA检测。结果1682例患者TCT检查结果异常者158例,占9.39%,其中不典型鳞状细胞和腺细胞病变(ASC-US)63例(3.75%),低度鳞状上皮内病变(LSIL)44例(2.61%),高度鳞状上皮内病变(HSIL)45例(2.67%),鳞状上皮细胞癌(SCC)6例(0.36%)。158例TCT检查异常者HR-HPV DNA检测阳性85例,阳性率53.78%;HR-HPV DNA阳性率分布为:ASC-US23.81%(15/63)、LSIL65.90%(29/44)、HSIL77.77%(35/45)、SCC100.00%(6/6),阳性率随宫颈病变级别升高而升高。结论TCT和HR-HPV DNA检查是筛查宫颈癌前病变的有效方法,二者结合有利于提高宫颈癌及癌前病变的检出率。Objective To explore the value of thinprep cytologic test（TCT）and high-risk hu- man papillomavirus DNA （HR-HPV DNA） detection of cervical disease screening. Methods Of the second affiliated hospital of nanchang university, 1 682 cases of out-patient gynecological patients with cervicitis TCT inspection, and one of TCT in patients with abnornal test abnormal test results for HR-HPV DNA testing. Results In the 1 682 patients,158 cases showed abnormal results for TCT,accounting for 9.39% ,ASC-US 63 cases （3.75%） ,LSIL 44 cases （9.61%） ,HSIL 45 cases （2.67%）, SCC 6 cases （0. 36 percent）. In 158 patients with abnormal cytology, there were 85 showing HR-HPV DNA testing positive,the positive rate was 53.78%, HR-HPV DNA positive rate for distribution：ASC-US 23.81% （15/63）,LSIL 65.90 % （29/44）, HSIL 77.77% （35/45） ,SCC 100.00%（6/6）. HR-HPV DNA positive rate of cervical lesions with high-level and higher. Conclusion TCT and HR-HPV DNA screening for cervical cancer screening may be an effective way to precancerous lesions, the combination will help improve cervical cancer and precancerous lesion detection rate.

关 键 词：液基细胞学 宫颈癌 筛查 人乳头瘤状病毒 

分 类 号：R711.32[医药卫生—妇产科学]